7CJB

VHL recognizes hydroxyproline in RIPK1

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000151	cellular_component	ubiquitin ligase complex
B	0001222	molecular_function	transcription corepressor binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0016567	biological_process	protein ubiquitination
B	0030891	cellular_component	VCB complex
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0070449	cellular_component	elongin complex
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0140958	biological_process	target-directed miRNA degradation
B	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
B	2000104	biological_process	negative regulation of DNA-templated DNA replication
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000151	cellular_component	ubiquitin ligase complex
F	0001222	molecular_function	transcription corepressor binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0016567	biological_process	protein ubiquitination
F	0030891	cellular_component	VCB complex
F	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
F	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0065003	biological_process	protein-containing complex assembly
F	0070449	cellular_component	elongin complex
F	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
F	0140958	biological_process	target-directed miRNA degradation
F	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
F	2000104	biological_process	negative regulation of DNA-templated DNA replication
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000151	cellular_component	ubiquitin ligase complex
J	0001222	molecular_function	transcription corepressor binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006351	biological_process	DNA-templated transcription
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006368	biological_process	transcription elongation by RNA polymerase II
J	0016567	biological_process	protein ubiquitination
J	0030891	cellular_component	VCB complex
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0070449	cellular_component	elongin complex
J	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
J	0140958	biological_process	target-directed miRNA degradation
J	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
J	2000104	biological_process	negative regulation of DNA-templated DNA replication
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000151	cellular_component	ubiquitin ligase complex
N	0001222	molecular_function	transcription corepressor binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006351	biological_process	DNA-templated transcription
N	0006367	biological_process	transcription initiation at RNA polymerase II promoter
N	0006368	biological_process	transcription elongation by RNA polymerase II
N	0016567	biological_process	protein ubiquitination
N	0030891	cellular_component	VCB complex
N	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
N	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0065003	biological_process	protein-containing complex assembly
N	0070449	cellular_component	elongin complex
N	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
N	0140958	biological_process	target-directed miRNA degradation
N	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
N	2000104	biological_process	negative regulation of DNA-templated DNA replication
O	0006511	biological_process	ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue GOL E 301

Chain	Residue
E	ARG161

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site_id	AC2
Number of Residues	2
Details	binding site for residue GOL I 301

Chain	Residue
I	ARG82
I	ARG161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	195
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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