7CFS
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Acid-sensing ion channel 1 | polymer | 477 | 54701.3 | 3 | UniProt (P78348) Pfam (PF00858) | Homo sapiens (Human) | ASIC1,Amiloride-sensitive cation channel 2,neuronal,Brain sodium channel 2,BNaC2 |
| 2 | D, E, H, I, K... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 3 | F, J, M (A, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (65082) PubChem (363416) PubChem (45489984) PubChem (500055) PubChem (60078761) PubChem (57163942) PubChem (73440805) PubChem (89891013) PubChem (13301926) PubChem (13301927) PubChem (99567469) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (137392566) PubChem (137496323) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (155804219) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (169132514) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 4 | G (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) |
Sequence modifications
A, B, C: 1 - 468 (UniProt: P78348)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 164103.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2810.4 | |
| All* | Total formula weight | 166914.3 |
