7CFS

Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Acid-sensing ion channel 1	polymer	477	54701.3	3	UniProt (P78348) Pfam (PF00858) In PDB	Homo sapiens (Human)	ASIC1,Amiloride-sensitive cation channel 2,neuronal,Brain sodium channel 2,BNaC2
2	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
3	A, B, C	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	3	Chemie (Y01)
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A, B, C: 1 - 468 (UniProt: P78348)

PDB	External Database	Details
Met -8	-	initiating methionine
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	164103.9
Non-Polymers*	Number of molecules	10
	Total formula weight	2810.4
All*	Total formula weight	166914.3

*Water molecules are not included.