7CFK
Structure of the CBS domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with the novel inhibitor IGN95a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hemolysin | polymer | 179 | 20328.9 | 2 | UniProt (A0A109QFA5) Pfam (PF00571) | Thermus parvatiensis | |
| 2 | C, E (A, B) | (2S)-2-[(6-azanyl-9H-purin-8-yl)sulfanyl]butanoic acid | non-polymer | 253.3 | 2 | Chemie (FX6) | |||
| 3 | D (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 183 - 361 (UniProt: A0A109QFA5)
| PDB | External Database | Details |
|---|---|---|
| Ala 282 | Cys 282 | engineered mutation |
| Ile 336 | Thr 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40657.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 701.8 | |
| All* | Total formula weight | 41359.5 |
