7CE3

Crystal structure of human IDH3 holoenzyme in APO form.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	polymer	366	39638.6	2	UniProt (P50213) Pfam (PF00180)	Homo sapiens (Human)	IDH3 alpha subunit,Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha
2	B (B)	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	polymer	357	39142.9	1	UniProt (P51553) Pfam (PF00180)	Homo sapiens (Human)	IDH3 gamma subunit,Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma
3	D (D)	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	polymer	359	39979.0	1	UniProt (O43837) Pfam (PF00180)	Homo sapiens (Human)	IDH3 beta subunit,Isocitric dehydrogenase subunit beta,NAD(+)-specific ICDH subunit beta

Sequence modifications

B: 1 - 354 (UniProt: P51553)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

D: 1 - 340 (UniProt: O43837)

PDB	External Database	Details
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Glu 341	-	expression tag
Ile 342	-	expression tag
Cys 343	-	expression tag
Arg 344	-	expression tag
Arg 345	-	expression tag
Val 346	-	expression tag
Lys 347	-	expression tag
Asp 348	-	expression tag
Leu 349	-	expression tag
Asp 350	-	expression tag
Glu 351	-	expression tag
Asn 352	-	expression tag
Leu 353	-	expression tag
Tyr 354	-	expression tag
Phe 355	-	expression tag
Gln 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	158399.1
All*	Total formula weight	158399.1

*Water molecules are not included.