7CCC
The structure of the actin filament uncapping complex mediated by twinfilin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Actin, alpha skeletal muscle | polymer | 377 | 42110.0 | 2 | UniProt (P68135) Pfam (PF00022) | Oryctolagus cuniculus (Rabbit) | Alpha-actin-1 |
| 2 | B (B) | Twinfilin-1 | polymer | 350 | 40341.7 | 1 | UniProt (Q12792) Pfam (PF00241) | Homo sapiens (Human) | Protein A6,Protein tyrosine kinase 9 |
| 3 | C (C) | F-actin-capping protein subunit alpha | polymer | 286 | 32980.7 | 1 | UniProt (Q5RKN9) Pfam (PF01267) UniProt (by SIFTS) (P47753) | Mus musculus (Mouse) | |
| 4 | D (D) | F-actin-capping protein subunit beta | polymer | 272 | 30669.8 | 1 | UniProt (Q923G3) Pfam (PF01115) | Mus musculus (Mouse) | |
| 5 | F, H (A, E) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | G, I (A, E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 7 | J, K, L, M, N (A, B, C, D, E) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
C: 1 - 286 (UniProt: Q5RKN9)
| PDB | External Database | Details |
|---|---|---|
| Val 222 | Ile 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 188212.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 934.6 | |
| All* | Total formula weight | 189146.7 |
