7C7Q

Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Gamma-aminobutyric acid type B receptor subunit 1	polymer	879	99082.7	1	UniProt (Q9UBS5) Pfam (PF00084) Pfam (PF01094) Pfam (PF00003)	Homo sapiens (Human)	Gb1
2	B (B)	Gamma-aminobutyric acid type B receptor subunit 2	polymer	769	86812.4	1	UniProt (O75899) Pfam (PF01094) Pfam (PF00003)	Homo sapiens (Human)	Gb2,G-protein coupled receptor 51,HG20
3	C, D, E, F, G... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
4	H (A)	(3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one	non-polymer		330.3	1	Chemie (FN0)
5	I (A)	baclofen	non-polymer		213.7	1	Chemie (2C0)

Sequence modifications

A: 15 - 862 (UniProt: Q9UBS5)

PDB	External Database	Details
Met -1	-	expression tag
Lys 0	-	expression tag
Thr 1	-	expression tag
Ile 2	-	expression tag
Ile 3	-	expression tag
Ala 4	-	expression tag
Leu 5	-	expression tag
Ser 6	-	expression tag
Tyr 7	-	expression tag
Ile 8	-	expression tag
Phe 9	-	expression tag
Cys 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Phe 13	-	expression tag
Ala 14	-	expression tag
Glu 863	-	expression tag
Val 864	-	expression tag
Leu 865	-	expression tag
Phe 866	-	expression tag
Gln 867	-	expression tag
Gly 868	-	expression tag
Pro 869	-	expression tag
His 870	-	expression tag
His 871	-	expression tag
His 872	-	expression tag
His 873	-	expression tag
His 874	-	expression tag
His 875	-	expression tag
His 876	-	expression tag
His 877	-	expression tag

B: 41 - 780 (UniProt: O75899)

PDB	External Database	Details
Met 12	-	expression tag
Lys 13	-	expression tag
Thr 14	-	expression tag
Ile 15	-	expression tag
Ile 16	-	expression tag
Ala 17	-	expression tag
Leu 18	-	expression tag
Ser 19	-	expression tag
Tyr 20	-	expression tag
Ile 21	-	expression tag
Phe 22	-	expression tag
Cys 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Phe 26	-	expression tag
Ala 27	-	expression tag
Asp 28	-	expression tag
Tyr 29	-	expression tag
Lys 30	-	expression tag
Asp 31	-	expression tag
Asp 32	-	expression tag
Asp 33	-	expression tag
Asp 34	-	expression tag
Lys 35	-	expression tag
Gly 36	-	expression tag
Ser 37	-	expression tag
Gly 38	-	expression tag
Gly 39	-	expression tag
Ser 40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	185895.1
Non-Polymers*	Number of molecules	10
	Total formula weight	2313.7
All*	Total formula weight	188208.8

*Water molecules are not included.