7C7P
Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3C-like proteinase | polymer | 306 | 33825.5 | 2 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | C, E (A, B) | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide | non-polymer | 681.9 | 2 | Chemie (SV6) PubChem (23634854) PubChem (58991585) PubChem (59235545) PubChem (59235547) PubChem (59519874) PubChem (59235546) PubChem (59235541) PubChem (59356439) PubChem (70905009) PubChem (68458137) PubChem (68573663) PubChem (70315220) PubChem (74074001) PubChem (78358367) PubChem (78358368) PubChem (78358369) PubChem (70702388) PubChem (70904955) PubChem (89431687) PubChem (89827385) PubChem (101878924) PubChem (117627200) PubChem (117844340) PubChem (117844342) PubChem (117879778) PubChem (142694691) | |||
| 3 | D, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 526 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67651.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1434.6 | |
| All* | Total formula weight | 69085.7 |
