7C7P
Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue SV6 A 401 |
| Chain | Residue |
| A | THR26 |
| A | GLU166 |
| A | LEU167 |
| A | ARG188 |
| A | GLN189 |
| A | GLN192 |
| A | HOH574 |
| A | HOH577 |
| A | HOH584 |
| A | HOH637 |
| A | HOH668 |
| A | HIS41 |
| A | MET49 |
| A | ASN142 |
| A | GLY143 |
| A | SER144 |
| A | CYS145 |
| A | HIS164 |
| A | MET165 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ILE106 |
| A | GLN107 |
| A | GLN110 |
| A | HOH738 |
| B | THR224 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 402 |
| Chain | Residue |
| B | ARG4 |
| B | LYS5 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide FK3 B 401 and CYS B 145 |
| Chain | Residue |
| B | THR26 |
| B | LEU27 |
| B | ASN28 |
| B | HIS41 |
| B | GLY143 |
| B | SER144 |
| B | GLY146 |
| B | SER147 |
| B | HIS163 |
| B | HIS164 |
| B | ASP187 |
| B | GLN189 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32198291","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"39223933","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
