7C2M
Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with NITD-349
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Chimera of drug exporters of the RND superfamily-like protein and Endolysin | polymer | 934 | 103006.5 | 1 | UniProt (I7G2R2) UniProt (A0A097J809) Pfam (PF03176) UniProt (by SIFTS) (A0QP27) In PDB | Mycolicibacterium smegmatis MC2 155 | Lysis protein,Lysozyme,Muramidase |
2 | A | N-(4,4-dimethylcyclohexyl)-4,6-bis(fluoranyl)-1H-indole-2-carboxamide | non-polymer | 306.4 | 1 | Chemie (FFU) | |||
3 | A | alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside | non-polymer | 510.6 | 5 | Chemie (L6T) | |||
4 | A | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID | non-polymer | 190.2 | 2 | Chemie (MHA) |
Sequence modifications
A: 1 - 748 (UniProt: I7G2R2)
A: 751 - 910 (UniProt: A0A097J809)
PDB | External Database | Details |
---|---|---|
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Ser -2 | - | expression tag |
Asn -1 | - | expression tag |
Ala 0 | - | expression tag |
Glu 749 | - | linker |
Phe 750 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 803 | Cys 54 | engineered mutation |
Ala 846 | Cys 97 | engineered mutation |
Glu 911 | - | expression tag |
Phe 912 | - | expression tag |
His 913 | - | expression tag |
Leu 914 | - | expression tag |
Gly 915 | - | expression tag |
Gly 916 | - | expression tag |
Ile 917 | - | expression tag |
Lys 918 | - | expression tag |
Ala 919 | - | expression tag |
Phe 920 | - | expression tag |
His 921 | - | expression tag |
His 922 | - | expression tag |
His 923 | - | expression tag |
His 924 | - | expression tag |
His 925 | - | expression tag |
His 926 | - | expression tag |
His 927 | - | expression tag |
His 928 | - | expression tag |
His 929 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 103006.5 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3239.7 | |
All* | Total formula weight | 106246.2 |