7C2M
Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with NITD-349
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue FFU A 1001 |
| Chain | Residue |
| A | ILE249 |
| A | ILE253 |
| A | ASP256 |
| A | VAL638 |
| A | GLY641 |
| A | LEU642 |
| A | ASP645 |
| A | TYR646 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue L6T A 1002 |
| Chain | Residue |
| A | ARG288 |
| A | THR289 |
| A | PHE292 |
| A | SER652 |
| A | GLN-3 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue L6T A 1003 |
| Chain | Residue |
| A | GLN40 |
| A | TYR44 |
| A | LEU55 |
| A | ASP58 |
| A | ARG63 |
| A | ASP64 |
| A | ASP144 |
| A | ALA175 |
| A | HIS239 |
| A | PHE240 |
| A | ILE427 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue L6T A 1004 |
| Chain | Residue |
| A | THR66 |
| A | SER67 |
| A | THR121 |
| A | VAL122 |
| A | MET125 |
| A | LEU171 |
| A | GLN442 |
| A | PHE445 |
| A | PHE452 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue L6T A 1005 |
| Chain | Residue |
| A | HIS615 |
| A | GLY616 |
| A | LEU619 |
| A | MET620 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue L6T A 1006 |
| Chain | Residue |
| A | ASN621 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue MHA A 1007 |
| Chain | Residue |
| A | ASP759 |
| A | THR891 |
| A | PRO892 |
| A | ASN893 |
| A | ARG894 |
| A | LYS918 |
| A | ALA919 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MHA A 1008 |
| Chain | Residue |
| A | GLY618 |
| A | GLY862 |
| A | PHE863 |
| A | ASN865 |
| A | SER866 |
| A | ASN881 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 69 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 330 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OR2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AJG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Part of the proton transportation network","evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32512002","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
