7C2I
Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 2'-O-methyltransferase | polymer | 305 | 34315.3 | 1 | UniProt (P0DTD1) Pfam (PF06460) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,Non-structural protein 16,nsp16,Replicase polyprotein 1ab |
2 | B | Non-structural protein 10 | polymer | 144 | 15214.4 | 1 | UniProt (P0DTD1) Pfam (PF09401) In PDB | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,nsp10,Growth factor-like peptide,GFL,Replicase polyprotein 1ab |
3 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
4 | B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P0DTD1)
B: 1 - 139 (UniProt: P0DTD1)
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Leu -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49529.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 529.3 | |
All* | Total formula weight | 50059.0 |