7BZ2
Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 395 | 45812.6 | 1 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37346.8 | 1 | UniProt (P62871) Pfam (PF00400) In PDB | Bos taurus (Bovine) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 78 | 8805.2 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (Bovine) | G gamma-I |
4 | N | Nb35 nanobody | polymer | 161 | 17483.7 | 1 | Lama glama | ||
5 | R | Beta2 adrenergic receptor | polymer | 367 | 42010.8 | 1 | Pfam (PF00001) UniProt (by SIFTS) (P07550) In PDB | Homo sapiens | |
6 | R | ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide | non-polymer | 344.4 | 1 | Chemie (H98) |
Sequence modifications
A: 1 - 394 (UniProt: P63092)
B: 1 - 340 (UniProt: P62871)
G: 1 - 71 (UniProt: P63212)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 304 | Arg 304 | conflict |
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ser 68 | Cys 68 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 151459.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 344.4 | |
All* | Total formula weight | 151803.5 |