7BYI

Structure of SHMT2 in complex with CBX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine hydroxymethyltransferase, mitochondrial	polymer	483	53480.7	1	UniProt (P34897) Pfam (PF00464) In PDB	Homo sapiens (Human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	B	Serine hydroxymethyltransferase, mitochondrial	polymer	483	53225.4	1	UniProt (P34897) Pfam (PF00464) In PDB	Homo sapiens (Human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
3	A, B	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	B	CARBENOXOLONE	non-polymer		570.8	2	Chemie (CBO)
6		water	water		18.0	78	Chemie (HOH)

Sequence modifications

A: 22 - 504 (UniProt: P34897)

PDB	External Database	Details
Gly 261	Ala 261	conflict
Ala 343	Cys 343	conflict

B: 22 - 504 (UniProt: P34897)

PDB	External Database	Details
Gly 196	Lys 196	conflict
Ala 198	Asn 198	conflict
Ala 307	Ile 307	conflict
Gly 370	Tyr 370	conflict
Tyr 371	Ser 371	conflict
Gly 391	Leu 391	conflict
Gly 392	Asp 392	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	106706.2
Non-Polymers*	Number of molecules	5
	Total formula weight	1437.6
All*	Total formula weight	108143.7

*Water molecules are not included.