7BYI
Structure of SHMT2 in complex with CBX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine hydroxymethyltransferase, mitochondrial | polymer | 483 | 53480.7 | 1 | UniProt (P34897) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | B (B) | Serine hydroxymethyltransferase, mitochondrial | polymer | 483 | 53225.4 | 1 | UniProt (P34897) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 3 | C, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | E, F (B) | CARBENOXOLONE | non-polymer | 570.8 | 2 | Chemie (CBO) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 22 - 504 (UniProt: P34897)
B: 22 - 504 (UniProt: P34897)
| PDB | External Database | Details |
|---|---|---|
| Gly 261 | Ala 261 | conflict |
| Ala 343 | Cys 343 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 196 | Lys 196 | conflict |
| Ala 198 | Asn 198 | conflict |
| Ala 307 | Ile 307 | conflict |
| Gly 370 | Tyr 370 | conflict |
| Tyr 371 | Ser 371 | conflict |
| Gly 391 | Leu 391 | conflict |
| Gly 392 | Asp 392 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 106706.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1437.6 | |
| All* | Total formula weight | 108143.7 |
