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7BYI

Structure of SHMT2 in complex with CBX

Functional Information from GO Data
ChainGOidnamespacecontents
A0002082biological_processregulation of oxidative phosphorylation
A0003682molecular_functionchromatin binding
A0004372molecular_functionglycine hydroxymethyltransferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0006544biological_processglycine metabolic process
A0006545biological_processglycine biosynthetic process
A0006563biological_processL-serine metabolic process
A0006564biological_processL-serine biosynthetic process
A0006730biological_processone-carbon metabolic process
A0008284biological_processpositive regulation of cell population proliferation
A0008732molecular_functionL-allo-threonine aldolase activity
A0015630cellular_componentmicrotubule cytoskeleton
A0016597molecular_functionamino acid binding
A0016740molecular_functiontransferase activity
A0019264biological_processglycine biosynthetic process from serine
A0030170molecular_functionpyridoxal phosphate binding
A0034340biological_processresponse to type I interferon
A0035999biological_processtetrahydrofolate interconversion
A0042645cellular_componentmitochondrial nucleoid
A0042802molecular_functionidentical protein binding
A0046653biological_processtetrahydrofolate metabolic process
A0051262biological_processprotein tetramerization
A0051289biological_processprotein homotetramerization
A0070062cellular_componentextracellular exosome
A0070129biological_processregulation of mitochondrial translation
A0070536biological_processprotein K63-linked deubiquitination
A0070552cellular_componentBRISC complex
A1903715biological_processregulation of aerobic respiration
B0002082biological_processregulation of oxidative phosphorylation
B0003682molecular_functionchromatin binding
B0004372molecular_functionglycine hydroxymethyltransferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0006544biological_processglycine metabolic process
B0006545biological_processglycine biosynthetic process
B0006563biological_processL-serine metabolic process
B0006564biological_processL-serine biosynthetic process
B0006730biological_processone-carbon metabolic process
B0008284biological_processpositive regulation of cell population proliferation
B0008732molecular_functionL-allo-threonine aldolase activity
B0015630cellular_componentmicrotubule cytoskeleton
B0016597molecular_functionamino acid binding
B0016740molecular_functiontransferase activity
B0019264biological_processglycine biosynthetic process from serine
B0030170molecular_functionpyridoxal phosphate binding
B0034340biological_processresponse to type I interferon
B0035999biological_processtetrahydrofolate interconversion
B0042645cellular_componentmitochondrial nucleoid
B0042802molecular_functionidentical protein binding
B0046653biological_processtetrahydrofolate metabolic process
B0051262biological_processprotein tetramerization
B0051289biological_processprotein homotetramerization
B0070062cellular_componentextracellular exosome
B0070129biological_processregulation of mitochondrial translation
B0070536biological_processprotein K63-linked deubiquitination
B0070552cellular_componentBRISC complex
B1903715biological_processregulation of aerobic respiration
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue PO4 A 701
ChainResidue
ASER142
BGLY326
AGLY143
ASER144
ATHR277
AHIS279
AHOH822
BTYR96
BTYR141
BGLY325

site_idAC2
Number of Residues2
Detailsbinding site for residue PEG A 702
ChainResidue
ALYS459
BALA463

site_idAC3
Number of Residues7
Detailsbinding site for residue CBO B 601
ChainResidue
ALEU166
AILE183
ASER226
AARG425
BGLU98
BTYR105
BTYR106

site_idAC4
Number of Residues6
Detailsbinding site for residue CBO B 602
ChainResidue
AGLU98
AHOH829
BLEU166
BHIS171
BLEU172
BTYR176

site_idAC5
Number of Residues10
Detailsbinding site for residue PO4 B 603
ChainResidue
ATYR96
AGLY325
AGLY326
BSER142
BGLY143
BSER144
BHIS171
BTHR277
BHIS279
BLYS280

Functional Information from PROSITE/UniProt
site_idPS00096
Number of Residues17
DetailsSHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DIvTTTTHKTLrGARSG
ChainResidueDetails
BASP272-GLY288
AASP272-GLY288

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS103
BLYS181
BGLY196
BLYS297
BLYS356
BLYS464
BLYS469
BLYS474

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:29180469
ChainResidueDetails
BLYS280

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER470

220113

PDB entries from 2024-05-22

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