7BVQ

Structure of human beta1 adrenergic receptor bound to carazolol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Endolysin,Beta-1 adrenergic receptor chimera	polymer	462	52235.9	2	UniProt (D9IEF7) Pfam (PF00959) Pfam (PF00001) UniProt (by SIFTS) (P08588)	Enterobacteria phage T4	Lysozyme,Muramidase
2	C (C)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	D (A)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
4	E, S (A, B)	(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol	non-polymer		298.4	2	Chemie (CAU)
5	F, G, H, I, J... (A, B)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
6	L, V (A, B)	(2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate	non-polymer		300.4	2	Chemie (1WV)
7	M (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8	N, O (A)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
9	P, Q, R, W (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	4	Chemie (PG4)
10	X, Y (A, B)	water	water		18.0	121	Chemie (HOH)

Sequence modifications

A, B: 892 - 1051 (UniProt: D9IEF7)

PDB	External Database	Details
Asp 884	-	expression tag
Tyr 885	-	expression tag
Lys 886	-	expression tag
Asp 887	-	expression tag
Asp 888	-	expression tag
Asp 889	-	expression tag
Asp 890	-	expression tag
Ala 891	-	expression tag
Thr 944	Cys 54	engineered mutation
Ala 987	Cys 97	engineered mutation
Ala 1052	-	linker
Ala 1053	-	linker

A, B: 1054 - 1399 (PDB: 7BVQ)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104471.8
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	20
	Total formula weight	3536.9
All*	Total formula weight	108351.0

*Water molecules are not included.