7BVC
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Integral membrane indolylacetylinositol arabinosyltransferase EmbA | polymer | 1088 | 116561.9 | 1 | UniProt (A0R613) Pfam (PF17689) Pfam (PF04602) Pfam (PF14896) In PDB | Mycolicibacterium smegmatis MC2 155 | Probable arabinosyltransferase B |
2 | B | Integral membrane indolylacetylinositol arabinosyltransferase EmbB | polymer | 1100 | 119077.7 | 1 | UniProt (I7GAQ2) Pfam (PF17689) Pfam (PF04602) Pfam (PF14896) UniProt (by SIFTS) (A0R614) In PDB | Mycolicibacterium smegmatis MC2 155 | |
3 | P | Meromycolate extension acyl carrier protein | polymer | 99 | 10743.9 | 1 | UniProt (A0R0B3) Pfam (PF00550) In PDB | Mycolicibacterium smegmatis MC2 155 | ACP |
4 | A, B | CARDIOLIPIN | non-polymer | 1464.0 | 2 | Chemie (CDL) | |||
5 | A | [(2Z,6E,10E,14Z,18E,22Z,26Z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl] [(2S,3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl] hydrogen phosphate | non-polymer | 911.3 | 1 | Chemie (F8L) | |||
6 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
7 | B | 4'-PHOSPHOPANTETHEINE | non-polymer | 358.3 | 1 | Chemie (PNS) | |||
8 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
9 | B | Ethambutol | non-polymer | 204.3 | 1 | Chemie (95E) |
Sequence modifications
A: 1 - 1080 (UniProt: A0R613)
B: 1 - 1082 (UniProt: I7GAQ2)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Lys 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 1083 | - | expression tag |
Leu 1084 | - | expression tag |
Gly 1085 | - | expression tag |
Gly 1086 | - | expression tag |
Ile 1087 | - | expression tag |
Lys 1088 | - | expression tag |
Ala 1089 | - | expression tag |
Phe 1090 | - | expression tag |
His 1091 | - | expression tag |
His 1092 | - | expression tag |
His 1093 | - | expression tag |
His 1094 | - | expression tag |
His 1095 | - | expression tag |
His 1096 | - | expression tag |
His 1097 | - | expression tag |
His 1098 | - | expression tag |
His 1099 | - | expression tag |
His 1100 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 246383.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 4577.2 | |
All* | Total formula weight | 250960.6 |