7BVC
Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052636 | molecular_function | arabinosyltransferase activity |
| A | 0071555 | biological_process | cell wall organization |
| A | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052636 | molecular_function | arabinosyltransferase activity |
| B | 0071555 | biological_process | cell wall organization |
| B | 0071766 | biological_process | Actinobacterium-type cell wall biogenesis |
| P | 0000035 | molecular_function | acyl binding |
| P | 0000036 | molecular_function | acyl carrier activity |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0005829 | cellular_component | cytosol |
| P | 0006629 | biological_process | lipid metabolic process |
| P | 0006631 | biological_process | fatty acid metabolic process |
| P | 0006633 | biological_process | fatty acid biosynthetic process |
| P | 0009245 | biological_process | lipid A biosynthetic process |
| P | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CDL A 1101 |
| Chain | Residue |
| A | MET518 |
| B | PHE569 |
| A | ARG522 |
| A | ARG586 |
| A | GLY643 |
| A | HIS650 |
| B | GLU507 |
| B | ARG554 |
| B | TRP558 |
| B | PHE565 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue F8L A 1102 |
| Chain | Residue |
| A | ASP261 |
| A | TYR264 |
| A | ASN265 |
| A | ARG365 |
| A | PRO408 |
| A | GLN409 |
| A | TYR472 |
| A | LEU550 |
| A | THR553 |
| A | TRP555 |
| A | GLN558 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 1103 |
| Chain | Residue |
| A | GLU831 |
| A | ASP931 |
| A | ASN933 |
| A | GLN938 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue PNS B 1201 |
| Chain | Residue |
| B | MET251 |
| B | HIS252 |
| B | ARG253 |
| B | PRO256 |
| B | THR257 |
| B | TRP259 |
| B | ARG407 |
| P | SER41 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 1202 |
| Chain | Residue |
| B | ARG389 |
| B | GLN431 |
| B | THR576 |
| B | TRP578 |
| B | HIS581 |
| B | 95E1203 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 95E B 1203 |
| Chain | Residue |
| B | ASP285 |
| B | TYR288 |
| B | ASN304 |
| B | GLU313 |
| B | TYR320 |
| B | TRP972 |
| B | PO41202 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue CDL B 1204 |
| Chain | Residue |
| A | ARG422 |
| A | TYR487 |
| A | TRP535 |
| B | ARG545 |
| B | ARG609 |
| B | SER616 |
| B | SER662 |
| B | LEU667 |
| B | PHE670 |
| B | HIS673 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 1205 |
| Chain | Residue |
| B | ASP936 |
| B | SER938 |
| B | SER940 |
| B | ASP943 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20094657","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
