7BTT
A X-ray cocrystal structure of XMU-MP-5 bound to the ALK kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ALK tyrosine kinase receptor | polymer | 320 | 35934.2 | 1 | UniProt (Q9UM73) Pfam (PF07714) In PDB | Homo sapiens (Human) | Anaplastic lymphoma kinase |
| 2 | A | 2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5H-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone | non-polymer | 563.7 | 1 | Chemie (F8R) | |||
| 3 | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gln 1091 | - | expression tag |
| Gly 1092 | - | expression tag |
| Gly 1281 | Ser 1281 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35934.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 563.7 | |
| All* | Total formula weight | 36497.9 |
