7BO2

Notum Fragment_130 (4H-thieno[3,2-c]chromene-2-carboxylic acid)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Palmitoleoyl-protein carboxylesterase NOTUM	polymer	382	43438.0	1	UniProt (Q6P988) Pfam (PF03283)	Homo sapiens (Human)	hNOTUM
2	B, D, E, F, G... (A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
3	C (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	I, J, K, L, M... (A)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
5	P (A)	4~{H}-thieno[3,2-c]chromene-2-carboxylic acid	non-polymer		232.3	1	Chemie (U62)
6	Q, R, S (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
7	T (A)	water	water		18.0	141	Chemie (HOH)

Sequence modifications

A: 81 - 451 (UniProt: Q6P988)

PDB	External Database	Details
Glu 78	-	expression tag
Thr 79	-	expression tag
Gly 80	-	expression tag
Ser 330	Cys 330	engineered mutation
Gly 452	-	expression tag
Thr 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43438.0
Non-Polymers*	Number of molecules	18
	Total formula weight	1698.7
All*	Total formula weight	45136.7

*Water molecules are not included.