7BFP

Structure of the Integrator cleavage module with INTS4/9/11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Integrator complex subunit 9	polymer	658	73891.2	1	UniProt (Q9NV88) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382) In PDB	Homo sapiens (Human)	Int9,Protein related to CPSF subunits of 74 kDa,RC-74
2	C	Integrator complex subunit 4	polymer	979	110164.8	1	UniProt (Q96HW7) Pfam (PF20168) Pfam (PF13646) In PDB	Homo sapiens (Human)	Int4
3	B	Integrator complex subunit 11	polymer	645	72690.0	1	UniProt (Q5TA45) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386) In PDB	Homo sapiens (Human)	Int11,Cleavage and polyadenylation-specific factor 3-like protein,CPSF3-like protein,Protein related to CPSF subunits of 68 kDa,RC-68
4	U	Unknown	polymer	36	3081.8	1		Homo sapiens

Sequence modifications

C: 1 - 963 (UniProt: Q96HW7)

PDB	External Database	Details
Met -15	-	initiating methionine
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Pro -6	-	expression tag
Pro -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag

B: 1 - 600 (UniProt: Q5TA45)

PDB	External Database	Details
Met -44	-	initiating methionine
Asp -43	-	expression tag
Glu -42	-	expression tag
Lys -41	-	expression tag
Thr -40	-	expression tag
Thr -39	-	expression tag
Gly -38	-	expression tag
Trp -37	-	expression tag
Arg -36	-	expression tag
Gly -35	-	expression tag
Gly -34	-	expression tag
His -33	-	expression tag
Val -32	-	expression tag
Val -31	-	expression tag
Glu -30	-	expression tag
Gly -29	-	expression tag
Leu -28	-	expression tag
Ala -27	-	expression tag
Gly -26	-	expression tag
Glu -25	-	expression tag
Leu -24	-	expression tag
Glu -23	-	expression tag
Gln -22	-	expression tag
Leu -21	-	expression tag
Arg -20	-	expression tag
Ala -19	-	expression tag
Arg -18	-	expression tag
Leu -17	-	expression tag
Glu -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Pro -13	-	expression tag
Gln -12	-	expression tag
Gly -11	-	expression tag
Gln -10	-	expression tag
Arg -9	-	expression tag
Glu -8	-	expression tag
Pro -7	-	expression tag
Pro -6	-	expression tag
Pro -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Leu 447	Pro 447	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	259827.8
All*	Total formula weight	259827.8

*Water molecules are not included.