7BFP

Structure of the Integrator cleavage module with INTS4/9/11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016180	biological_process	snRNA processing
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0032039	cellular_component	integrator complex
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0034472	biological_process	snRNA 3'-end processing
A	0090101	biological_process	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
A	0090287	biological_process	regulation of cellular response to growth factor stimulus
A	0160232	cellular_component	INTAC complex
A	0160240	biological_process	RNA polymerase II transcription initiation surveillance
B	0004521	molecular_function	RNA endonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016180	biological_process	snRNA processing
B	0016787	molecular_function	hydrolase activity
B	0032039	cellular_component	integrator complex
B	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
B	0034472	biological_process	snRNA 3'-end processing
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0160232	cellular_component	INTAC complex
B	0160240	biological_process	RNA polymerase II transcription initiation surveillance
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0016180	biological_process	snRNA processing
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0032039	cellular_component	integrator complex
C	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
C	0160232	cellular_component	INTAC complex
C	0160240	biological_process	RNA polymerase II transcription initiation surveillance

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q95TS5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

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Residue

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site_id	SWS_FT_FI4
Number of Residues	34
Details	Repeat: {"description":"HEAT 4"}

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Residue

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site_id	SWS_FT_FI5
Number of Residues	36
Details	Repeat: {"description":"HEAT 5"}

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Residue

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site_id	SWS_FT_FI6
Number of Residues	5
Details	Motif: {"description":"HXHXDH motif"}

Chain

Residue

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"28396433","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32697989","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33548203","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38570683","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RBZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI13
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9VAH9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI14
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"36454007","evidenceCode":"ECO:0000269"}]}

Chain

Residue

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