7BC7
Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Proton-coupled folate transporter | polymer | 480 | 51366.6 | 1 | UniProt (E6Y8U5) Pfam (PF07690) UniProt (by SIFTS) (F1NJ67) In PDB | Gallus gallus (Chicken) | |
| 2 | B | nanobody | polymer | 123 | 13460.0 | 1 | Lama glama | ||
| 3 | A | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID | non-polymer | 427.4 | 1 | Chemie (LYA) |
Sequence modifications
A: 1 - 473 (UniProt: E6Y8U5)
| PDB | External Database | Details |
|---|---|---|
| Gly 474 | - | expression tag |
| Glu 475 | - | expression tag |
| Asn 476 | - | expression tag |
| Leu 477 | - | expression tag |
| Tyr 478 | - | expression tag |
| Phe 479 | - | expression tag |
| Gln 480 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64826.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 427.4 | |
| All* | Total formula weight | 65254.0 |
