7BAQ
Crystal structure of the cAMP-dependent protein kinase A cocrystallized with a chiral ligand (S- and E-configuration) and PKI (5-24)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41033.8 | 1 | UniProt (P25321) Pfam (PF00069) | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase inhibitor alpha | polymer | 18 | 1973.2 | 1 | UniProt (P63248) | Mus musculus | PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform |
| 3 | C (A) | (S,E)-3-(2-(3-bromo-4-hydroxybenzylidene)hydrazineyl)-2-(3-chlorophenyl)-3-oxopropan-1-aminium | non-polymer | 396.7 | 1 | Chemie (T82) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 194 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43007.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 396.7 | |
| All* | Total formula weight | 43403.6 |
