7B91
Structure of a minimal SF3B core in complex with pladienolide D (form I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Splicing factor 3B subunit 3 | polymer | 899 | 100722.1 | 1 | UniProt (Q15393) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130,STAF130,Spliceosome-associated protein 130,SAP 130 |
| 2 | B | Splicing factor 3B subunit 5 | polymer | 86 | 10149.4 | 1 | UniProt (Q9BWJ5) Pfam (PF07189) In PDB | Homo sapiens (Human) | SF3b5,Pre-mRNA-splicing factor SF3b 10 kDa subunit |
| 3 | C | Splicing factor 3B subunit 1 | polymer | 852 | 96615.7 | 1 | UniProt (O75533) In PDB | Homo sapiens (Human) | Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155,Spliceosome-associated protein 155,SAP 155 |
| 4 | D | PHD finger-like domain-containing protein 5A | polymer | 108 | 11670.5 | 1 | UniProt (Q7RTV0) Pfam (PF03660) In PDB | Homo sapiens (Human) | PHD finger-like domain protein 5A,Splicing factor 3B-associated 14 kDa protein,SF3b14b |
| 5 | D | [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate | non-polymer | 552.7 | 1 | Chemie (T2Z) | |||
| 6 | D | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 760 (UniProt: Q15393)
A: 768 - 1198 (UniProt: Q15393)
D: 1 - 98 (UniProt: Q7RTV0)
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Arg -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 761 | - | linker |
| Gly 762 | - | linker |
| Asn 763 | - | linker |
| Gly 764 | - | linker |
| Asn 765 | - | linker |
| Ser 766 | - | linker |
| Gly 767 | - | linker |
| - | Glu 1068 | deletion |
| - | Asp 1069 | deletion |
| - | Pro 1070 | deletion |
| - | Thr 1071 | deletion |
| - | Gly 1072 | deletion |
| - | Asn 1073 | deletion |
| - | Lys 1074 | deletion |
| - | Ala 1075 | deletion |
| - | Leu 1076 | deletion |
| - | Trp 1077 | deletion |
| - | Asp 1078 | deletion |
| - | Arg 1079 | deletion |
| - | Gly 1080 | deletion |
| - | Leu 1081 | deletion |
| - | Leu 1082 | deletion |
| - | Asn 1083 | deletion |
| - | Gly 1084 | deletion |
| - | Ala 1085 | deletion |
| Phe 1199 | - | expression tag |
| Asp 1200 | - | expression tag |
| Tyr 1201 | - | expression tag |
| Lys 1202 | - | expression tag |
| Asp 1203 | - | expression tag |
| Asp 1204 | - | expression tag |
| Asp 1205 | - | expression tag |
| Asp 1206 | - | expression tag |
| Lys 1207 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 219157.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 748.9 | |
| All* | Total formula weight | 219906.7 |
