7B91
Structure of a minimal SF3B core in complex with pladienolide D (form I)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005634 | cellular_component | nucleus |
| B | 0000124 | cellular_component | SAGA complex |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0005684 | cellular_component | U2-type spliceosomal complex |
| B | 0005686 | cellular_component | U2 snRNP |
| B | 0005689 | cellular_component | U12-type spliceosomal complex |
| B | 0006282 | biological_process | regulation of DNA repair |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0043484 | biological_process | regulation of RNA splicing |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0071005 | cellular_component | U2-type precatalytic spliceosome |
| B | 0071011 | cellular_component | precatalytic spliceosome |
| B | 1903241 | biological_process | U2-type prespliceosome assembly |
| B | 1990935 | molecular_function | splicing factor binding |
| C | 0000245 | biological_process | spliceosomal complex assembly |
| C | 0003729 | molecular_function | mRNA binding |
| D | 0000398 | biological_process | mRNA splicing, via spliceosome |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH |
| Chain | Residue | Details |
| A | PHE287-HIS293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28541300, ECO:0007744|PDB:5IFE, ECO:0007744|PDB:5SYB |
| Chain | Residue | Details |
| D | CYS46 | |
| D | CYS49 | |
| D | CYS58 | |
| D | CYS61 | |
| D | CYS72 | |
| D | CYS75 | |
| D | CYS85 | |
| D | CYS11 | |
| D | CYS23 | |
| D | CYS26 | |
| D | CYS30 | |
| D | CYS33 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Interaction with SF3B3 => ECO:0000269|PubMed:27720643 |
| Chain | Residue | Details |
| D | VAL17 | |
| A | LYS1171 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P83870 |
| Chain | Residue | Details |
| D | ALA2 | |
| C | CYS677 | |
| C | GLU1205 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| D | LYS3 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER94 | |
| C | LYS562 |
