7B66
Structure of NUDT15 R139H Mutant in complex with TH7755
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nucleotide triphosphate diphosphatase NUDT15 | polymer | 164 | 18616.0 | 4 | UniProt (Q9NV35) Pfam (PF00293) | Homo sapiens (Human) | MutT homolog 2,MTH2,Nucleoside diphosphate-linked moiety X motif 15,Nudix motif 15,Nucleoside diphosphate-linked to another moiety X hydrolase 15,Nudix hydrolase 15 |
| 2 | E, F, G, H (A, B, C, D) | (R)-6-((2-methyl-4-(1-methyl-1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one | non-polymer | 454.5 | 4 | Chemie (SYW) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 164 (UniProt: Q9NV35)
| PDB | External Database | Details |
|---|---|---|
| His 139 | Arg 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74463.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1818.0 | |
| All* | Total formula weight | 76281.8 |
