7B66

Structure of NUDT15 R139H Mutant in complex with TH7755

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0000302	biological_process	response to reactive oxygen species
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006195	biological_process	purine nucleotide catabolic process
A	0006203	biological_process	dGTP catabolic process
A	0006950	biological_process	response to stress
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042262	biological_process	DNA protection
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	1901292	biological_process	nucleoside phosphate catabolic process
B	0000278	biological_process	mitotic cell cycle
B	0000302	biological_process	response to reactive oxygen species
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006195	biological_process	purine nucleotide catabolic process
B	0006203	biological_process	dGTP catabolic process
B	0006950	biological_process	response to stress
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042262	biological_process	DNA protection
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	1901292	biological_process	nucleoside phosphate catabolic process
C	0000278	biological_process	mitotic cell cycle
C	0000302	biological_process	response to reactive oxygen species
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006195	biological_process	purine nucleotide catabolic process
C	0006203	biological_process	dGTP catabolic process
C	0006950	biological_process	response to stress
C	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C	0042178	biological_process	xenobiotic catabolic process
C	0042262	biological_process	DNA protection
C	0044715	molecular_function	8-oxo-dGDP phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	1901292	biological_process	nucleoside phosphate catabolic process
D	0000278	biological_process	mitotic cell cycle
D	0000302	biological_process	response to reactive oxygen species
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006195	biological_process	purine nucleotide catabolic process
D	0006203	biological_process	dGTP catabolic process
D	0006950	biological_process	response to stress
D	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
D	0016787	molecular_function	hydrolase activity
D	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D	0042178	biological_process	xenobiotic catabolic process
D	0042262	biological_process	DNA protection
D	0044715	molecular_function	8-oxo-dGDP phosphatase activity
D	0046872	molecular_function	metal ion binding
D	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	1901292	biological_process	nucleoside phosphate catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU63
A	GLU67
B	GLU63
B	GLU67
C	GLU63
C	GLU67
D	GLU63
D	GLU67

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