7B4E
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R282W mutant bound to DNA and MQ: R282W-DNA-MQ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22534.6 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B (B) | DNA target | polymer | 11 | 3335.2 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E, G (A) | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 3 | Chemie (QN8) | |||
| 5 | F (A) | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 1 | Chemie (QNN) | |||
| 6 | H (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 7 | I, J (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | K, L (A, B) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Trp 282 | Arg 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25869.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 940.6 | |
| All* | Total formula weight | 26810.3 |
