7B4D
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 200 | 22521.6 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B (C) | DNA target | polymer | 12 | 3664.4 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, F, G (A) | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 3 | Chemie (QNN) | |||
| 5 | E (A) | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one | non-polymer | 139.2 | 1 | Chemie (QN8) | |||
| 6 | H, I, J (A) | FORMIC ACID | non-polymer | 46.0 | 3 | Chemie (FMT) | |||
| 7 | K, L (A, C) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Arg 240 | Ser 240 | engineered mutation |
| Cys 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26186.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 760.3 | |
| All* | Total formula weight | 26946.3 |
