7AW6
The extracellular region of CD33 with bound sialoside analogue P22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Myeloid cell surface antigen CD33 | polymer | 252 | 27917.8 | 2 | UniProt (P20138) Pfam (PF07686) Pfam (PF00047) | Homo sapiens (Human) | Sialic acid-binding Ig-like lectin 3,Siglec-3,gp67 |
| 2 | C, D, E, F, H... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 3 | G, M (A, B) | 2-aminoethyl 5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->6)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside | non-polymer | 973.0 | 2 | Chemie (FVP) | |||
| 4 | N (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | O, P (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 232 (UniProt: P20138)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | initiating methionine |
| Gly -9 | - | expression tag |
| Ile -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Met -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Val 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Ser 9 | - | expression tag |
| Val 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Met 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Cys 15 | - | expression tag |
| Val 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Glu 18 | - | expression tag |
| Thr 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Gly 233 | - | expression tag |
| Thr 234 | - | expression tag |
| Lys 235 | - | expression tag |
| His 236 | - | expression tag |
| His 237 | - | expression tag |
| His 238 | - | expression tag |
| His 239 | - | expression tag |
| His 240 | - | expression tag |
| His 241 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 55835.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4156.0 | |
| All* | Total formula weight | 59991.5 |
