7AR4
Crystal structure of beta-catenin in complex with cyclic peptide inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Catenin beta-1 | polymer | 536 | 58412.7 | 1 | UniProt (P35222) Pfam (PF00514) | Homo sapiens (Human) | Beta-catenin |
| 2 | B (PaP) | Cadherin-1 | polymer | 16 | 1714.9 | 1 | UniProt (P09803) | Mus musculus | ARC-1,Epithelial cadherin,E-cadherin,Uvomorulin |
| 3 | C (AAA) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 4 | D (AAA) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F (AAA, PaP) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
AAA: 134 - 665 (UniProt: P35222)
PaP: 1 - 16 (UniProt: P09803)
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | expression tag |
| Ala 131 | - | expression tag |
| Met 132 | - | expression tag |
| Ala 133 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Bal 1 | Glu 783 | engineered mutation |
| Dpr 8 | Ala 790 | engineered mutation |
| Asp 10 | Thr 792 | engineered mutation |
| Ser 11 | Leu 793 | engineered mutation |
| Leu 12 | Met 794 | engineered mutation |
| Leu 13 | Ser 795 | engineered mutation |
| Phe 15 | Pro 797 | engineered mutation |
| Bal 16 | Gln 798 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60127.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 273.8 | |
| All* | Total formula weight | 60401.4 |
