7AOT
The Fk1 domain of FKBP51 in complex with (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 128 | 14026.1 | 1 | UniProt (Q13451) Pfam (PF00254) In PDB | Homo sapiens (Human) | PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
2 | A | (2R,5S,12R)-12-cyclohexyl-2-[2-(3,4-dimethoxyphenyl)ethyl]-3,19-dioxa-10,13,16-triazatricyclo[18.3.1.0-5,10]tetracosa- 1(24),20,22-triene-4,11,14,17-tetrone | non-polymer | 635.7 | 1 | Chemie (RTQ) | |||
3 | water | water | 18.0 | 218 | Chemie (HOH) |
Sequence modifications
A: 16 - 140 (UniProt: Q13451)
PDB | External Database | Details |
---|---|---|
Gly 13 | - | expression tag |
Ala 14 | - | expression tag |
Pro 15 | - | expression tag |
Thr 19 | Ala 19 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 14026.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 635.7 | |
All* | Total formula weight | 14661.8 |