7AKJ
Structure of the SARS-CoV spike glycoprotein in complex with the 47D11 neutralizing antibody Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G (C, B, A) | Spike glycoprotein | polymer | 1193 | 132302.7 | 3 | UniProt (Q5DIC5) Pfam (PF16451) Pfam (PF09408) Pfam (PF01601) UniProt (by SIFTS) (P59594) | SARS coronavirus WH20 | S glycoprotein,E2,Peplomer protein |
| 2 | C, E, H (G, E, H) | 47D11 neutralizing antibody heavy chain | polymer | 121 | 13205.8 | 3 | Homo sapiens | ||
| 3 | D, F, I (F, D, L) | 47D11 neutralizing antibody light chain | polymer | 106 | 11350.6 | 3 | Homo sapiens | ||
| 4 | AA, J, L, M, O... (a, I, K, M, O...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K, Q, W (J, Q, W) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 6 | N, T, Z (N, T, Z) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1543.4 | 3 | In PDB GlyTouCan (G78231ZN) | |||
| 7 | AB, BA, BB, CA, CB... (A, C, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 36 | Chemie (NAG) |
Sequence modifications
C, B, A: 18 - 1160 (UniProt: Q5DIC5)
| PDB | External Database | Details |
|---|---|---|
| Pro 968 | Lys 968 | conflict |
| Pro 969 | Val 969 | conflict |
| Leu 1161 | - | expression tag |
| Ile 1162 | - | expression tag |
| Lys 1163 | - | expression tag |
| Gly 1164 | - | expression tag |
| Ser 1165 | - | expression tag |
| Gly 1166 | - | expression tag |
| Tyr 1167 | - | expression tag |
| Ile 1168 | - | expression tag |
| Pro 1169 | - | expression tag |
| Glu 1170 | - | expression tag |
| Ala 1171 | - | expression tag |
| Pro 1172 | - | expression tag |
| Arg 1173 | - | expression tag |
| Asp 1174 | - | expression tag |
| Gly 1175 | - | expression tag |
| Gln 1176 | - | expression tag |
| Ala 1177 | - | expression tag |
| Tyr 1178 | - | expression tag |
| Val 1179 | - | expression tag |
| Arg 1180 | - | expression tag |
| Lys 1181 | - | expression tag |
| Asp 1182 | - | expression tag |
| Gly 1183 | - | expression tag |
| Glu 1184 | - | expression tag |
| Trp 1185 | - | expression tag |
| Val 1186 | - | expression tag |
| Leu 1187 | - | expression tag |
| Leu 1188 | - | expression tag |
| Ser 1189 | - | expression tag |
| Thr 1190 | - | expression tag |
| Phe 1191 | - | expression tag |
| Leu 1192 | - | expression tag |
| Ile 1193 | - | expression tag |
| Lys 1194 | - | expression tag |
| Leu 1195 | - | expression tag |
| Val 1196 | - | expression tag |
| Pro 1197 | - | expression tag |
| Arg 1198 | - | expression tag |
| Gly 1199 | - | expression tag |
| Ser 1200 | - | expression tag |
| Leu 1201 | - | expression tag |
| Glu 1202 | - | expression tag |
| Trp 1203 | - | expression tag |
| Ser 1204 | - | expression tag |
| His 1205 | - | expression tag |
| Pro 1206 | - | expression tag |
| Gln 1207 | - | expression tag |
| Phe 1208 | - | expression tag |
| Glu 1209 | - | expression tag |
| Lys 1210 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 470577.3 | |
| Branched | Number of molecules | 18 |
| Total formula weight | 11434.6 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 7963.5 | |
| All* | Total formula weight | 489975.4 |
