7AGQ

Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Mycocerosic acid synthase	polymer	439	46530.5	2	UniProt (Q02251) Pfam (PF16197) Pfam (PF00698)	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
2	C, E (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

A, B: 447 - 871 (UniProt: Q02251)

PDB	External Database	Details
Met 435	-	initiating methionine
Gly 436	-	expression tag
Ser 437	-	expression tag
Ser 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
Ser 445	-	expression tag
Ser 446	-	expression tag
Phe 726	Ser 726	engineered mutation
Gly 872	-	cloning artifact
Ser 873	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	93061.0
Non-Polymers*	Number of molecules	3
	Total formula weight	210.2
All*	Total formula weight	93271.2

*Water molecules are not included.