7AEM
Studies Towards a Reversible EGFR C797S Triple Mutant Inhibitor Series
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 346 | 39325.3 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | non-polymer | 584.1 | 1 | Chemie (6GY) | |||
| 3 | C (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 677 | - | expression tag |
| Ser 678 | - | expression tag |
| Thr 679 | - | expression tag |
| Ser 680 | - | expression tag |
| Leu 681 | - | expression tag |
| Tyr 682 | - | expression tag |
| Lys 683 | - | expression tag |
| Lys 684 | - | expression tag |
| Ala 685 | - | expression tag |
| Gly 686 | - | expression tag |
| Ser 687 | - | expression tag |
| Glu 688 | - | expression tag |
| Asn 689 | - | expression tag |
| Leu 690 | - | expression tag |
| Tyr 691 | - | expression tag |
| Phe 692 | - | expression tag |
| Gln 693 | - | expression tag |
| Gly 694 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39325.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 584.1 | |
| All* | Total formula weight | 39909.4 |
