7ADP
Cryo-EM structure of human ER membrane protein complex in GDN detergent
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ER membrane protein complex subunit 1 | polymer | 993 | 111886.1 | 1 | UniProt (Q8N766) Pfam (PF13360) Pfam (PF07774) In PDB | Homo sapiens (Human) | |
| 2 | B | ER membrane protein complex subunit 2 | polymer | 297 | 34882.5 | 1 | UniProt (Q15006) Pfam (PF22890) In PDB | Homo sapiens (Human) | Tetratricopeptide repeat protein 35,TPR repeat protein 35 |
| 3 | C | ER membrane protein complex subunit 3 | polymer | 261 | 29981.9 | 1 | UniProt (Q9P0I2) Pfam (PF01956) In PDB | Homo sapiens (Human) | Transmembrane protein 111 |
| 4 | D | ER membrane protein complex subunit 4 | polymer | 183 | 20104.6 | 1 | UniProt (Q5J8M3) Pfam (PF06417) In PDB | Homo sapiens (Human) | Cell proliferation-inducing gene 17 protein,Transmembrane protein 85 |
| 5 | E | Membrane magnesium transporter 1 | polymer | 139 | 15703.8 | 1 | UniProt (Q8N4V1) Pfam (PF10270) In PDB | Homo sapiens (Human) | ER membrane protein complex subunit 5,Transmembrane protein 32 |
| 6 | F | ER membrane protein complex subunit 6 | polymer | 110 | 12029.2 | 1 | UniProt (Q9BV81) Pfam (PF07019) In PDB | Homo sapiens (Human) | Transmembrane protein 93 |
| 7 | H | ER membrane protein complex subunit 8 | polymer | 210 | 23807.1 | 1 | UniProt (O43402) Pfam (PF03665) In PDB | Homo sapiens (Human) | Neighbor of COX4,Protein FAM158B |
| 8 | I | ER membrane protein complex subunit 10 | polymer | 263 | 27446.9 | 1 | UniProt (Q5UCC4) Pfam (PF21203) In PDB | Homo sapiens (Human) | Hematopoietic signal peptide-containing membrane domain-containing protein 1 |
| 9 | A, I | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
E: 1 - 131 (UniProt: Q8N4V1)
I: 2 - 262 (UniProt: Q5UCC4)
| PDB | External Database | Details |
|---|---|---|
| Asp 132 | - | expression tag |
| Tyr 133 | - | expression tag |
| Lys 134 | - | expression tag |
| Asp 135 | - | expression tag |
| Asp 136 | - | expression tag |
| Asp 137 | - | expression tag |
| Asp 138 | - | expression tag |
| Lys 139 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 275842.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 276505.8 |
