7AA5
Human TRPV4 structure in presence of 4a-PDD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein | polymer | 935 | 106241.8 | 4 | UniProt (Q9HBA0) UniProt (P42212) Pfam (PF00023) Pfam (PF00520) Pfam (PF01353) | Homo sapiens (Human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
| 2 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
A, B, C, D: 148 - 787 (UniProt: Q9HBA0)
A, B, C, D: 802 - 1037 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| Met 116 | - | initiating methionine |
| Asp 117 | - | expression tag |
| Tyr 118 | - | expression tag |
| Lys 119 | - | expression tag |
| Asp 120 | - | expression tag |
| Asp 121 | - | expression tag |
| Asp 122 | - | expression tag |
| Asp 123 | - | expression tag |
| Lys 124 | - | expression tag |
| Ser 125 | - | expression tag |
| Ser 126 | - | expression tag |
| Met 127 | - | expression tag |
| Gly 128 | - | expression tag |
| Ser 129 | - | expression tag |
| Arg 130 | - | expression tag |
| Thr 131 | - | expression tag |
| Ser 132 | - | expression tag |
| Leu 133 | - | expression tag |
| Tyr 134 | - | expression tag |
| Lys 135 | - | expression tag |
| Lys 136 | - | expression tag |
| Ala 137 | - | expression tag |
| Gly 138 | - | expression tag |
| Ser 139 | - | expression tag |
| Leu 140 | - | expression tag |
| Glu 141 | - | expression tag |
| Val 142 | - | expression tag |
| Leu 143 | - | expression tag |
| Phe 144 | - | expression tag |
| Gln 145 | - | expression tag |
| Gly 146 | - | expression tag |
| Pro 147 | - | expression tag |
| Asp 651 | Asn 651 | conflict |
| Glu 788 | - | linker |
| Asn 789 | - | linker |
| Leu 790 | - | linker |
| Tyr 791 | - | linker |
| Phe 792 | - | linker |
| Gln 793 | - | linker |
| Gly 794 | - | linker |
| Ala 795 | - | linker |
| Ala 796 | - | linker |
| Gly 797 | - | linker |
| Ser 798 | - | linker |
| Gly 799 | - | linker |
| Glu 800 | - | linker |
| Phe 801 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 863 | Phe 64 | conflict |
| Thr 864 | Ser 65 | conflict |
| Arg 879 | Gln 80 | conflict |
| Ser 898 | Phe 99 | conflict |
| Thr 952 | Met 153 | conflict |
| Ala 962 | Val 163 | conflict |
| Ala 1038 | - | expression tag |
| Ser 1039 | - | expression tag |
| Gly 1040 | - | expression tag |
| His 1041 | - | expression tag |
| His 1042 | - | expression tag |
| His 1043 | - | expression tag |
| His 1044 | - | expression tag |
| His 1045 | - | expression tag |
| His 1046 | - | expression tag |
| His 1047 | - | expression tag |
| His 1048 | - | expression tag |
| His 1049 | - | expression tag |
| His 1050 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 424967.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 425007.4 |
