7A5P
Human C Complex Spliceosome - Medium-resolution PERIPHERY
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | 2 | U2 snRNA | polymer | 975 | 312349.7 | 1 | GenBank (36516) | Homo sapiens | |
2 | 5 | U5 snRNA | polymer | 116 | 36908.7 | 1 | GenBank (36515) | Homo sapiens (Human) | |
3 | 6 | U6 snRNA | polymer | 106 | 34098.3 | 1 | Homo sapiens | ||
4 | 8 | UNKNOWN | polymer | 204 | 17379.4 | 1 | Homo sapiens | ||
5 | A | Pre-mRNA-processing-splicing factor 8 | polymer | 2335 | 273974.3 | 1 | UniProt (Q6P2Q9) Pfam (PF08082) Pfam (PF08083) Pfam (PF10598) Pfam (PF10597) Pfam (PF10596) Pfam (PF12134) Pfam (PF01398) Pfam (PF08084) In PDB | Homo sapiens (Human) | 220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220 |
6 | C | SNW domain-containing protein 1 | polymer | 536 | 61610.7 | 1 | UniProt (Q13573) Pfam (PF02731) In PDB | Homo sapiens (Human) | Nuclear protein SkiP,Nuclear receptor coactivator NCoA-62,Ski-interacting protein |
7 | E | Pre-mRNA-processing factor 17 | polymer | 579 | 65612.2 | 1 | UniProt (O60508) Pfam (PF00400) In PDB | Homo sapiens (Human) | Cell division cycle 40 homolog,EH-binding protein 3,Ehb3,PRP17 homolog,hPRP17 |
8 | G, H, I, J | Pre-mRNA-processing factor 19 | polymer | 504 | 55245.5 | 4 | UniProt (Q9UMS4) Pfam (PF04564) Pfam (PF08606) Pfam (PF00400) In PDB | Homo sapiens (Human) | Nuclear matrix protein 200,PRP19/PSO4 homolog,hPso4,RING-type E3 ubiquitin transferase PRP19,Senescence evasion factor |
9 | K | Pre-mRNA-splicing factor SPF27 | polymer | 225 | 26163.4 | 1 | UniProt (O75934) Pfam (PF05700) In PDB | Homo sapiens (Human) | Breast carcinoma-amplified sequence 2,DNA amplified in mammary carcinoma 1 protein,Spliceosome-associated protein SPF 27 |
10 | L | Cell division cycle 5-like protein | polymer | 802 | 92406.9 | 1 | UniProt (Q99459) Pfam (PF13921) Pfam (PF11831) In PDB | Homo sapiens (Human) | Cdc5-like protein,Pombe cdc5-related protein |
11 | M | Pre-mRNA-splicing factor SYF1 | polymer | 855 | 100148.7 | 1 | UniProt (Q9HCS7) Pfam (PF13181) In PDB | Homo sapiens (Human) | Protein HCNP,XPA-binding protein 2 |
12 | N | Pre-mRNA-splicing factor SYF2 | polymer | 243 | 28780.5 | 1 | UniProt (O95926) Pfam (PF08231) In PDB | Homo sapiens (Human) | CCNDBP1-interactor,p29 |
13 | O | Crooked neck-like protein 1 | polymer | 848 | 100610.0 | 1 | UniProt (Q9BZJ0) Pfam (PF02184) In PDB | Homo sapiens (Human) | Crooked neck homolog,hCrn |
14 | P | Pre-mRNA-splicing factor RBM22 | polymer | 420 | 46959.6 | 1 | UniProt (Q9NW64) Pfam (PF21369) Pfam (PF00076) In PDB | Homo sapiens (Human) | RNA-binding motif protein 22,Zinc finger CCCH domain-containing protein 16 |
15 | S | Serine/arginine repetitive matrix protein 2 | polymer | 2752 | 300255.3 | 1 | UniProt (Q9UQ35) Pfam (PF08312) In PDB | Homo sapiens (Human) | 300 kDa nuclear matrix antigen,Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa,Ser/Arg-related nuclear matrix protein of 300 kDa,Splicing coactivator subunit SRm300,Tax-responsive enhancer element-binding protein 803,TaxREB803 |
16 | T | Pre-mRNA-splicing factor CWC22 homolog | polymer | 908 | 105646.6 | 1 | UniProt (Q9HCG8) Pfam (PF02854) Pfam (PF02847) In PDB | Homo sapiens (Human) | Nucampholin homolog,fSAPb |
17 | U | Intron-binding protein aquarius | polymer | 1485 | 173331.3 | 1 | UniProt (O60306) Pfam (PF16399) Pfam (PF21143) Pfam (PF21144) Pfam (PF13086) Pfam (PF13087) In PDB | Homo sapiens (Human) | Intron-binding protein of 160 kDa,IBP160 |
18 | W | U2 small nuclear ribonucleoprotein A' | polymer | 255 | 28484.6 | 1 | UniProt (P09661) Pfam (PF14580) In PDB | Homo sapiens (Human) | U2 snRNP A' |
19 | X | U2 small nuclear ribonucleoprotein B'' | polymer | 225 | 25524.4 | 1 | UniProt (P08579) Pfam (PF00076) In PDB | Homo sapiens (Human) | U2 snRNP B'' |
20 | Y | pre-mRNA | polymer | 324 | 103979.1 | 1 | Homo sapiens | ||
21 | a, l | Small nuclear ribonucleoprotein Sm D3 | polymer | 126 | 13940.3 | 2 | UniProt (P62318) Pfam (PF01423) In PDB | Homo sapiens (Human) | Sm-D3,snRNP core protein D3 |
22 | b, m | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 240 | 24642.1 | 2 | UniProt (P14678) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-B,Sm protein B/B',SmB/B' |
23 | c, n | Small nuclear ribonucleoprotein Sm D1 | polymer | 119 | 13310.7 | 2 | UniProt (P62314) Pfam (PF01423) In PDB | Homo sapiens (Human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
24 | d, h | Small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13551.9 | 2 | UniProt (P62316) Pfam (PF01423) In PDB | Homo sapiens (Human) | Sm-D2,snRNP core protein D2 |
25 | e, j | Small nuclear ribonucleoprotein E | polymer | 92 | 10817.6 | 2 | UniProt (P62304) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-E,Sm protein E,SmE |
26 | f, i | Small nuclear ribonucleoprotein F | polymer | 86 | 9734.2 | 2 | UniProt (P62306) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-F,Sm protein F,SmF |
27 | g, k | Small nuclear ribonucleoprotein G | polymer | 76 | 8508.1 | 2 | UniProt (P62308) Pfam (PF01423) In PDB | Homo sapiens (Human) | snRNP-G,Sm protein G,SmG |
28 | o | Peptidyl-prolyl cis-trans isomerase E | polymer | 301 | 33475.8 | 1 | UniProt (Q9UNP9) Pfam (PF00076) Pfam (PF00160) In PDB | Homo sapiens (Human) | PPIase E,Cyclophilin E,Cyclophilin-33,Rotamase E |
29 | p | WD repeat-containing protein 70 | polymer | 654 | 73306.2 | 1 | UniProt (Q9NW82) Pfam (PF00400) In PDB | Homo sapiens (Human) | |
30 | q | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 2136 | 244823.4 | 1 | UniProt (O75643) Pfam (PF21188) Pfam (PF18149) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) In PDB | Homo sapiens (Human) | Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD |
31 | r | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | polymer | 1227 | 140777.7 | 1 | UniProt (Q92620) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) In PDB | Homo sapiens (Human) | ATP-dependent RNA helicase DHX38,DEAH box protein 38 |
32 | s | Pre-mRNA-splicing factor ISY1 homolog | polymer | 285 | 33046.3 | 1 | UniProt (Q9ULR0) Pfam (PF06246) In PDB | Homo sapiens (Human) | |
33 | u | Splicing factor YJU2 | polymer | 323 | 37141.8 | 1 | UniProt (Q9BW85) Pfam (PF04502) In PDB | Homo sapiens (Human) | Coiled-coil domain-containing protein 94 |
34 | v | Protein mago nashi homolog | polymer | 146 | 17189.6 | 1 | UniProt (P61326) Pfam (PF02792) In PDB | Homo sapiens (Human) | |
35 | w | RNA-binding protein 8A | polymer | 174 | 19925.1 | 1 | UniProt (Q9Y5S9) Pfam (PF00076) In PDB | Homo sapiens (Human) | Binder of OVCA1-1,BOV-1,RNA-binding motif protein 8A,RNA-binding protein Y14,Ribonucleoprotein RBM8A |
36 | x | Protein FRG1 | polymer | 258 | 29227.5 | 1 | UniProt (Q14331) Pfam (PF06229) In PDB | Homo sapiens (Human) | FSHD region gene 1 protein |
37 | y | Eukaryotic initiation factor 4A-III | polymer | 411 | 46931.0 | 1 | UniProt (P38919) Pfam (PF00270) Pfam (PF00271) In PDB | Homo sapiens (Human) | eIF4A-III,ATP-dependent RNA helicase DDX48,ATP-dependent RNA helicase eIF4A-3,DEAD box protein 48,Eukaryotic initiation factor 4A-like NUK-34,Eukaryotic translation initiation factor 4A isoform 3,Nuclear matrix protein 265,hNMP 265 |
38 | z | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 | polymer | 646 | 73679.9 | 1 | UniProt (Q96BP3) Pfam (PF00400) Pfam (PF00160) In PDB | Homo sapiens (Human) | Spliceosome-associated cyclophilin |
Sequence modifications
W: 1 - 255 (UniProt: P09661)
r: 1 - 1227 (UniProt: Q92620)
PDB | External Database | Details |
---|---|---|
Asp 89 | Cys 89 | conflict |
Cys 119 | Ser 119 | conflict |
PDB | External Database | Details |
---|---|---|
Asn 855 | Gly 855 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 48 |
Total formula weight | 3093739.6 | |
All* | Total formula weight | 3093739.6 |