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7A5P

Human C Complex Spliceosome - Medium-resolution PERIPHERY

Functional Information from GO Data
ChainGOidnamespacecontents
A0000244biological_processspliceosomal tri-snRNP complex assembly
A0000375biological_processRNA splicing, via transesterification reactions
A0000398biological_processmRNA splicing, via spliceosome
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005682cellular_componentU5 snRNP
A0006397biological_processmRNA processing
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008380biological_processRNA splicing
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0017070molecular_functionU6 snRNA binding
A0030532cellular_componentsmall nuclear ribonucleoprotein complex
A0030619molecular_functionU1 snRNA binding
A0030620molecular_functionU2 snRNA binding
A0030623molecular_functionU5 snRNA binding
A0046540cellular_componentU4/U6 x U5 tri-snRNP complex
A0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
A0071005cellular_componentU2-type precatalytic spliceosome
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071007cellular_componentU2-type catalytic step 2 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0071222biological_processcellular response to lipopolysaccharide
A0071356biological_processcellular response to tumor necrosis factor
A0097157molecular_functionpre-mRNA intronic binding
A0140492molecular_functionmetal-dependent deubiquitinase activity
A1990904cellular_componentribonucleoprotein complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000398biological_processmRNA splicing, via spliceosome
C0003713molecular_functiontranscription coactivator activity
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0005112molecular_functionNotch binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0006357biological_processregulation of transcription by RNA polymerase II
C0006397biological_processmRNA processing
C0008024cellular_componentcyclin/CDK positive transcription elongation factor complex
C0008380biological_processRNA splicing
C0016363cellular_componentnuclear matrix
C0016604cellular_componentnuclear body
C0016607cellular_componentnuclear speck
C0016922molecular_functionnuclear receptor binding
C0019899molecular_functionenzyme binding
C0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
C0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C0042809molecular_functionnuclear vitamin D receptor binding
C0042974molecular_functionnuclear retinoic acid receptor binding
C0043923biological_processhost-mediated activation of viral transcription
C0045892biological_processnegative regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046332molecular_functionSMAD binding
C0048026biological_processpositive regulation of mRNA splicing, via spliceosome
C0048384biological_processretinoic acid receptor signaling pathway
C0048385biological_processregulation of retinoic acid receptor signaling pathway
C0050681molecular_functionnuclear androgen receptor binding
C0050769biological_processpositive regulation of neurogenesis
C0070562biological_processregulation of vitamin D receptor signaling pathway
C0070564biological_processpositive regulation of vitamin D receptor signaling pathway
C0071007cellular_componentU2-type catalytic step 2 spliceosome
C0071013cellular_componentcatalytic step 2 spliceosome
C0071300biological_processcellular response to retinoic acid
E0000398biological_processmRNA splicing, via spliceosome
E0003723molecular_functionRNA binding
E0003729molecular_functionmRNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005681cellular_componentspliceosomal complex
E0006397biological_processmRNA processing
E0008380biological_processRNA splicing
E0016607cellular_componentnuclear speck
E0071007cellular_componentU2-type catalytic step 2 spliceosome
E0071013cellular_componentcatalytic step 2 spliceosome
E1990403biological_processembryonic brain development
G0000077biological_processDNA damage checkpoint signaling
G0000209biological_processprotein polyubiquitination
G0000244biological_processspliceosomal tri-snRNP complex assembly
G0000245biological_processspliceosomal complex assembly
G0000398biological_processmRNA splicing, via spliceosome
G0000974cellular_componentPrp19 complex
G0001833biological_processinner cell mass cell proliferation
G0004842molecular_functionubiquitin-protein transferase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005662cellular_componentDNA replication factor A complex
G0005681cellular_componentspliceosomal complex
G0005737cellular_componentcytoplasm
G0005811cellular_componentlipid droplet
G0005819cellular_componentspindle
G0005856cellular_componentcytoskeleton
G0006281biological_processDNA repair
G0006303biological_processdouble-strand break repair via nonhomologous end joining
G0006397biological_processmRNA processing
G0006974biological_processDNA damage response
G0008104biological_processintracellular protein localization
G0008380biological_processRNA splicing
G0008610biological_processlipid biosynthetic process
G0010498biological_processproteasomal protein catabolic process
G0016020cellular_componentmembrane
G0016567biological_processprotein ubiquitination
G0016607cellular_componentnuclear speck
G0016740molecular_functiontransferase activity
G0034450molecular_functionubiquitin-ubiquitin ligase activity
G0035861cellular_componentsite of double-strand break
G0042802molecular_functionidentical protein binding
G0048026biological_processpositive regulation of mRNA splicing, via spliceosome
G0061630molecular_functionubiquitin protein ligase activity
G0070534biological_processprotein K63-linked ubiquitination
G0071006cellular_componentU2-type catalytic step 1 spliceosome
G0071007cellular_componentU2-type catalytic step 2 spliceosome
G0071013cellular_componentcatalytic step 2 spliceosome
H0000077biological_processDNA damage checkpoint signaling
H0000209biological_processprotein polyubiquitination
H0000244biological_processspliceosomal tri-snRNP complex assembly
H0000245biological_processspliceosomal complex assembly
H0000398biological_processmRNA splicing, via spliceosome
H0000974cellular_componentPrp19 complex
H0001833biological_processinner cell mass cell proliferation
H0004842molecular_functionubiquitin-protein transferase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005662cellular_componentDNA replication factor A complex
H0005681cellular_componentspliceosomal complex
H0005737cellular_componentcytoplasm
H0005811cellular_componentlipid droplet
H0005819cellular_componentspindle
H0005856cellular_componentcytoskeleton
H0006281biological_processDNA repair
H0006303biological_processdouble-strand break repair via nonhomologous end joining
H0006397biological_processmRNA processing
H0006974biological_processDNA damage response
H0008104biological_processintracellular protein localization
H0008380biological_processRNA splicing
H0008610biological_processlipid biosynthetic process
H0010498biological_processproteasomal protein catabolic process
H0016020cellular_componentmembrane
H0016567biological_processprotein ubiquitination
H0016607cellular_componentnuclear speck
H0016740molecular_functiontransferase activity
H0034450molecular_functionubiquitin-ubiquitin ligase activity
H0035861cellular_componentsite of double-strand break
H0042802molecular_functionidentical protein binding
H0048026biological_processpositive regulation of mRNA splicing, via spliceosome
H0061630molecular_functionubiquitin protein ligase activity
H0070534biological_processprotein K63-linked ubiquitination
H0071006cellular_componentU2-type catalytic step 1 spliceosome
H0071007cellular_componentU2-type catalytic step 2 spliceosome
H0071013cellular_componentcatalytic step 2 spliceosome
I0000077biological_processDNA damage checkpoint signaling
I0000209biological_processprotein polyubiquitination
I0000244biological_processspliceosomal tri-snRNP complex assembly
I0000245biological_processspliceosomal complex assembly
I0000398biological_processmRNA splicing, via spliceosome
I0000974cellular_componentPrp19 complex
I0001833biological_processinner cell mass cell proliferation
I0004842molecular_functionubiquitin-protein transferase activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005662cellular_componentDNA replication factor A complex
I0005681cellular_componentspliceosomal complex
I0005737cellular_componentcytoplasm
I0005811cellular_componentlipid droplet
I0005819cellular_componentspindle
I0005856cellular_componentcytoskeleton
I0006281biological_processDNA repair
I0006303biological_processdouble-strand break repair via nonhomologous end joining
I0006397biological_processmRNA processing
I0006974biological_processDNA damage response
I0008104biological_processintracellular protein localization
I0008380biological_processRNA splicing
I0008610biological_processlipid biosynthetic process
I0010498biological_processproteasomal protein catabolic process
I0016020cellular_componentmembrane
I0016567biological_processprotein ubiquitination
I0016607cellular_componentnuclear speck
I0016740molecular_functiontransferase activity
I0034450molecular_functionubiquitin-ubiquitin ligase activity
I0035861cellular_componentsite of double-strand break
I0042802molecular_functionidentical protein binding
I0048026biological_processpositive regulation of mRNA splicing, via spliceosome
I0061630molecular_functionubiquitin protein ligase activity
I0070534biological_processprotein K63-linked ubiquitination
I0071006cellular_componentU2-type catalytic step 1 spliceosome
I0071007cellular_componentU2-type catalytic step 2 spliceosome
I0071013cellular_componentcatalytic step 2 spliceosome
J0000077biological_processDNA damage checkpoint signaling
J0000209biological_processprotein polyubiquitination
J0000244biological_processspliceosomal tri-snRNP complex assembly
J0000245biological_processspliceosomal complex assembly
J0000398biological_processmRNA splicing, via spliceosome
J0000974cellular_componentPrp19 complex
J0001833biological_processinner cell mass cell proliferation
J0004842molecular_functionubiquitin-protein transferase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005662cellular_componentDNA replication factor A complex
J0005681cellular_componentspliceosomal complex
J0005737cellular_componentcytoplasm
J0005811cellular_componentlipid droplet
J0005819cellular_componentspindle
J0005856cellular_componentcytoskeleton
J0006281biological_processDNA repair
J0006303biological_processdouble-strand break repair via nonhomologous end joining
J0006397biological_processmRNA processing
J0006974biological_processDNA damage response
J0008104biological_processintracellular protein localization
J0008380biological_processRNA splicing
J0008610biological_processlipid biosynthetic process
J0010498biological_processproteasomal protein catabolic process
J0016020cellular_componentmembrane
J0016567biological_processprotein ubiquitination
J0016607cellular_componentnuclear speck
J0016740molecular_functiontransferase activity
J0034450molecular_functionubiquitin-ubiquitin ligase activity
J0035861cellular_componentsite of double-strand break
J0042802molecular_functionidentical protein binding
J0048026biological_processpositive regulation of mRNA splicing, via spliceosome
J0061630molecular_functionubiquitin protein ligase activity
J0070534biological_processprotein K63-linked ubiquitination
J0071006cellular_componentU2-type catalytic step 1 spliceosome
J0071007cellular_componentU2-type catalytic step 2 spliceosome
J0071013cellular_componentcatalytic step 2 spliceosome
K0000375biological_processRNA splicing, via transesterification reactions
K0000380biological_processalternative mRNA splicing, via spliceosome
K0000398biological_processmRNA splicing, via spliceosome
K0000974cellular_componentPrp19 complex
K0001541biological_processovarian follicle development
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005662cellular_componentDNA replication factor A complex
K0005681cellular_componentspliceosomal complex
K0005730cellular_componentnucleolus
K0005813cellular_componentcentrosome
K0006397biological_processmRNA processing
K0008380biological_processRNA splicing
K0016607cellular_componentnuclear speck
K0030163biological_processprotein catabolic process
K0048477biological_processoogenesis
K0048599biological_processoocyte development
K0051225biological_processspindle assembly
K0071007cellular_componentU2-type catalytic step 2 spliceosome
K0071013cellular_componentcatalytic step 2 spliceosome
L0000077biological_processDNA damage checkpoint signaling
L0000398biological_processmRNA splicing, via spliceosome
L0000974cellular_componentPrp19 complex
L0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
L0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
L0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
L0003677molecular_functionDNA binding
L0003723molecular_functionRNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005662cellular_componentDNA replication factor A complex
L0005681cellular_componentspliceosomal complex
L0005737cellular_componentcytoplasm
L0006281biological_processDNA repair
L0006355biological_processregulation of DNA-templated transcription
L0006357biological_processregulation of transcription by RNA polymerase II
L0006397biological_processmRNA processing
L0006974biological_processDNA damage response
L0008380biological_processRNA splicing
L0016020cellular_componentmembrane
L0016607cellular_componentnuclear speck
L0019904molecular_functionprotein domain specific binding
L0042802molecular_functionidentical protein binding
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0071007cellular_componentU2-type catalytic step 2 spliceosome
L0071013cellular_componentcatalytic step 2 spliceosome
L0071987molecular_functionWD40-repeat domain binding
M0000349biological_processgeneration of catalytic spliceosome for first transesterification step
M0000398biological_processmRNA splicing, via spliceosome
M0000974cellular_componentPrp19 complex
M0001824biological_processblastocyst development
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005681cellular_componentspliceosomal complex
M0006281biological_processDNA repair
M0006283biological_processtranscription-coupled nucleotide-excision repair
M0006351biological_processDNA-templated transcription
M0006396biological_processRNA processing
M0006397biological_processmRNA processing
M0006974biological_processDNA damage response
M0008380biological_processRNA splicing
M0016020cellular_componentmembrane
M0021987biological_processcerebral cortex development
M0071007cellular_componentU2-type catalytic step 2 spliceosome
M0071013cellular_componentcatalytic step 2 spliceosome
M0071014cellular_componentpost-mRNA release spliceosomal complex
N0000398biological_processmRNA splicing, via spliceosome
N0000974cellular_componentPrp19 complex
N0001701biological_processin utero embryonic development
N0003723molecular_functionRNA binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005681cellular_componentspliceosomal complex
N0006397biological_processmRNA processing
N0007095biological_processmitotic G2 DNA damage checkpoint signaling
N0007369biological_processgastrulation
N0008284biological_processpositive regulation of cell population proliferation
N0008380biological_processRNA splicing
N0016607cellular_componentnuclear speck
N0048568biological_processembryonic organ development
N0071007cellular_componentU2-type catalytic step 2 spliceosome
N0071013cellular_componentcatalytic step 2 spliceosome
N0071014cellular_componentpost-mRNA release spliceosomal complex
O0000245biological_processspliceosomal complex assembly
O0000398biological_processmRNA splicing, via spliceosome
O0000974cellular_componentPrp19 complex
O0003723molecular_functionRNA binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005681cellular_componentspliceosomal complex
O0006396biological_processRNA processing
O0006397biological_processmRNA processing
O0008380biological_processRNA splicing
O0016607cellular_componentnuclear speck
O0071007cellular_componentU2-type catalytic step 2 spliceosome
O0071013cellular_componentcatalytic step 2 spliceosome
O0071014cellular_componentpost-mRNA release spliceosomal complex
P0000398biological_processmRNA splicing, via spliceosome
P0000974cellular_componentPrp19 complex
P0003676molecular_functionnucleic acid binding
P0003723molecular_functionRNA binding
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005681cellular_componentspliceosomal complex
P0005737cellular_componentcytoplasm
P0006397biological_processmRNA processing
P0008270molecular_functionzinc ion binding
P0008380biological_processRNA splicing
P0017070molecular_functionU6 snRNA binding
P0033120biological_processpositive regulation of RNA splicing
P0036002molecular_functionpre-mRNA binding
P0042307biological_processpositive regulation of protein import into nucleus
P0045292biological_processmRNA cis splicing, via spliceosome
P0046827biological_processpositive regulation of protein export from nucleus
P0046872molecular_functionmetal ion binding
P0048306molecular_functioncalcium-dependent protein binding
P0071006cellular_componentU2-type catalytic step 1 spliceosome
P0071007cellular_componentU2-type catalytic step 2 spliceosome
P0071013cellular_componentcatalytic step 2 spliceosome
P0071466biological_processcellular response to xenobiotic stimulus
S0000398biological_processmRNA splicing, via spliceosome
S0003723molecular_functionRNA binding
S0003729molecular_functionmRNA binding
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005681cellular_componentspliceosomal complex
S0006397biological_processmRNA processing
S0008380biological_processRNA splicing
S0015030cellular_componentCajal body
S0016607cellular_componentnuclear speck
S0070742molecular_functionC2H2 zinc finger domain binding
S0071005cellular_componentU2-type precatalytic spliceosome
S0071007cellular_componentU2-type catalytic step 2 spliceosome
S0071013cellular_componentcatalytic step 2 spliceosome
T0000398biological_processmRNA splicing, via spliceosome
T0003723molecular_functionRNA binding
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005681cellular_componentspliceosomal complex
T0005829cellular_componentcytosol
T0006397biological_processmRNA processing
T0008380biological_processRNA splicing
T0016607cellular_componentnuclear speck
T0048024biological_processregulation of mRNA splicing, via spliceosome
T0071005cellular_componentU2-type precatalytic spliceosome
T0071006cellular_componentU2-type catalytic step 1 spliceosome
T0071007cellular_componentU2-type catalytic step 2 spliceosome
T0071013cellular_componentcatalytic step 2 spliceosome
U0000166molecular_functionnucleotide binding
U0000398biological_processmRNA splicing, via spliceosome
U0003723molecular_functionRNA binding
U0003724molecular_functionRNA helicase activity
U0003727molecular_functionsingle-stranded RNA binding
U0003729molecular_functionmRNA binding
U0004386molecular_functionhelicase activity
U0005515molecular_functionprotein binding
U0005524molecular_functionATP binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005681cellular_componentspliceosomal complex
U0006397biological_processmRNA processing
U0008380biological_processRNA splicing
U0016020cellular_componentmembrane
U0016787molecular_functionhydrolase activity
U0016887molecular_functionATP hydrolysis activity
U0034458molecular_function3'-5' RNA helicase activity
U0071007cellular_componentU2-type catalytic step 2 spliceosome
U0071013cellular_componentcatalytic step 2 spliceosome
W0000398biological_processmRNA splicing, via spliceosome
W0003723molecular_functionRNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005681cellular_componentspliceosomal complex
W0005684cellular_componentU2-type spliceosomal complex
W0005686cellular_componentU2 snRNP
W0006397biological_processmRNA processing
W0007283biological_processspermatogenesis
W0008380biological_processRNA splicing
W0016604cellular_componentnuclear body
W0016607cellular_componentnuclear speck
W0030532cellular_componentsmall nuclear ribonucleoprotein complex
W0030620molecular_functionU2 snRNA binding
W0071005cellular_componentU2-type precatalytic spliceosome
W0071007cellular_componentU2-type catalytic step 2 spliceosome
W0071013cellular_componentcatalytic step 2 spliceosome
W1903241biological_processU2-type prespliceosome assembly
W1990904cellular_componentribonucleoprotein complex
X0000398biological_processmRNA splicing, via spliceosome
X0001650cellular_componentfibrillar center
X0003676molecular_functionnucleic acid binding
X0003723molecular_functionRNA binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005681cellular_componentspliceosomal complex
X0005684cellular_componentU2-type spliceosomal complex
X0005685cellular_componentU1 snRNP
X0005686cellular_componentU2 snRNP
X0006397biological_processmRNA processing
X0008380biological_processRNA splicing
X0016607cellular_componentnuclear speck
X0030619molecular_functionU1 snRNA binding
X0036464cellular_componentcytoplasmic ribonucleoprotein granule
X0071005cellular_componentU2-type precatalytic spliceosome
X0071007cellular_componentU2-type catalytic step 2 spliceosome
X0071013cellular_componentcatalytic step 2 spliceosome
X0097525cellular_componentspliceosomal snRNP complex
X1903241biological_processU2-type prespliceosome assembly
X1990904cellular_componentribonucleoprotein complex
a0000243cellular_componentcommitment complex
a0000387biological_processspliceosomal snRNP assembly
a0000398biological_processmRNA splicing, via spliceosome
a0003723molecular_functionRNA binding
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005681cellular_componentspliceosomal complex
a0005682cellular_componentU5 snRNP
a0005683cellular_componentU7 snRNP
a0005684cellular_componentU2-type spliceosomal complex
a0005685cellular_componentU1 snRNP
a0005686cellular_componentU2 snRNP
a0005687cellular_componentU4 snRNP
a0005689cellular_componentU12-type spliceosomal complex
a0005697cellular_componenttelomerase holoenzyme complex
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0006396biological_processRNA processing
a0006397biological_processmRNA processing
a0006479biological_processprotein methylation
a0008380biological_processRNA splicing
a0016604cellular_componentnuclear body
a0019899molecular_functionenzyme binding
a0030532cellular_componentsmall nuclear ribonucleoprotein complex
a0034709cellular_componentmethylosome
a0034715cellular_componentpICln-Sm protein complex
a0034719cellular_componentSMN-Sm protein complex
a0036261biological_process7-methylguanosine cap hypermethylation
a0046540cellular_componentU4/U6 x U5 tri-snRNP complex
a0070034molecular_functiontelomerase RNA binding
a0071005cellular_componentU2-type precatalytic spliceosome
a0071007cellular_componentU2-type catalytic step 2 spliceosome
a0071011cellular_componentprecatalytic spliceosome
a0071013cellular_componentcatalytic step 2 spliceosome
a0071208molecular_functionhistone pre-mRNA DCP binding
a0071209molecular_functionU7 snRNA binding
a0097526cellular_componentspliceosomal tri-snRNP complex
a1903241biological_processU2-type prespliceosome assembly
a1990904cellular_componentribonucleoprotein complex
b0000387biological_processspliceosomal snRNP assembly
b0000398biological_processmRNA splicing, via spliceosome
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005681cellular_componentspliceosomal complex
b0005682cellular_componentU5 snRNP
b0005683cellular_componentU7 snRNP
b0005684cellular_componentU2-type spliceosomal complex
b0005685cellular_componentU1 snRNP
b0005686cellular_componentU2 snRNP
b0005687cellular_componentU4 snRNP
b0005689cellular_componentU12-type spliceosomal complex
b0005697cellular_componenttelomerase holoenzyme complex
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0006397biological_processmRNA processing
b0006479biological_processprotein methylation
b0008380biological_processRNA splicing
b0030532cellular_componentsmall nuclear ribonucleoprotein complex
b0034709cellular_componentmethylosome
b0034719cellular_componentSMN-Sm protein complex
b0036261biological_process7-methylguanosine cap hypermethylation
b0046540cellular_componentU4/U6 x U5 tri-snRNP complex
b0070034molecular_functiontelomerase RNA binding
b0070990molecular_functionsnRNP binding
b0071004cellular_componentU2-type prespliceosome
b0071005cellular_componentU2-type precatalytic spliceosome
b0071007cellular_componentU2-type catalytic step 2 spliceosome
b0071013cellular_componentcatalytic step 2 spliceosome
b0071204cellular_componenthistone pre-mRNA 3'end processing complex
b0071208molecular_functionhistone pre-mRNA DCP binding
b1903241biological_processU2-type prespliceosome assembly
b1990446molecular_functionU1 snRNP binding
b1990447molecular_functionU2 snRNP binding
b1990904cellular_componentribonucleoprotein complex
c0000243cellular_componentcommitment complex
c0000245biological_processspliceosomal complex assembly
c0000387biological_processspliceosomal snRNP assembly
c0000398biological_processmRNA splicing, via spliceosome
c0003723molecular_functionRNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005681cellular_componentspliceosomal complex
c0005682cellular_componentU5 snRNP
c0005684cellular_componentU2-type spliceosomal complex
c0005685cellular_componentU1 snRNP
c0005686cellular_componentU2 snRNP
c0005687cellular_componentU4 snRNP
c0005689cellular_componentU12-type spliceosomal complex
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0006396biological_processRNA processing
c0006397biological_processmRNA processing
c0008380biological_processRNA splicing
c0030532cellular_componentsmall nuclear ribonucleoprotein complex
c0034709cellular_componentmethylosome
c0034715cellular_componentpICln-Sm protein complex
c0034719cellular_componentSMN-Sm protein complex
c0036261biological_process7-methylguanosine cap hypermethylation
c0046540cellular_componentU4/U6 x U5 tri-snRNP complex
c0071005cellular_componentU2-type precatalytic spliceosome
c0071007cellular_componentU2-type catalytic step 2 spliceosome
c0071011cellular_componentprecatalytic spliceosome
c0071013cellular_componentcatalytic step 2 spliceosome
c0097526cellular_componentspliceosomal tri-snRNP complex
c1903241biological_processU2-type prespliceosome assembly
c1990446molecular_functionU1 snRNP binding
c1990904cellular_componentribonucleoprotein complex
d0000245biological_processspliceosomal complex assembly
d0000387biological_processspliceosomal snRNP assembly
d0000398biological_processmRNA splicing, via spliceosome
d0003723molecular_functionRNA binding
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005681cellular_componentspliceosomal complex
d0005682cellular_componentU5 snRNP
d0005684cellular_componentU2-type spliceosomal complex
d0005685cellular_componentU1 snRNP
d0005686cellular_componentU2 snRNP
d0005687cellular_componentU4 snRNP
d0005689cellular_componentU12-type spliceosomal complex
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0006397biological_processmRNA processing
d0008380biological_processRNA splicing
d0030532cellular_componentsmall nuclear ribonucleoprotein complex
d0034709cellular_componentmethylosome
d0034715cellular_componentpICln-Sm protein complex
d0034719cellular_componentSMN-Sm protein complex
d0036261biological_process7-methylguanosine cap hypermethylation
d0046540cellular_componentU4/U6 x U5 tri-snRNP complex
d0070062cellular_componentextracellular exosome
d0071005cellular_componentU2-type precatalytic spliceosome
d0071007cellular_componentU2-type catalytic step 2 spliceosome
d0071011cellular_componentprecatalytic spliceosome
d0071013cellular_componentcatalytic step 2 spliceosome
d0097525cellular_componentspliceosomal snRNP complex
d1903241biological_processU2-type prespliceosome assembly
d1990904cellular_componentribonucleoprotein complex
e0000245biological_processspliceosomal complex assembly
e0000387biological_processspliceosomal snRNP assembly
e0000398biological_processmRNA splicing, via spliceosome
e0003723molecular_functionRNA binding
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005654cellular_componentnucleoplasm
e0005681cellular_componentspliceosomal complex
e0005682cellular_componentU5 snRNP
e0005683cellular_componentU7 snRNP
e0005684cellular_componentU2-type spliceosomal complex
e0005685cellular_componentU1 snRNP
e0005686cellular_componentU2 snRNP
e0005687cellular_componentU4 snRNP
e0005689cellular_componentU12-type spliceosomal complex
e0005697cellular_componenttelomerase holoenzyme complex
e0005737cellular_componentcytoplasm
e0005829cellular_componentcytosol
e0006397biological_processmRNA processing
e0008380biological_processRNA splicing
e0030532cellular_componentsmall nuclear ribonucleoprotein complex
e0034709cellular_componentmethylosome
e0034715cellular_componentpICln-Sm protein complex
e0034719cellular_componentSMN-Sm protein complex
e0036261biological_process7-methylguanosine cap hypermethylation
e0046540cellular_componentU4/U6 x U5 tri-snRNP complex
e0071005cellular_componentU2-type precatalytic spliceosome
e0071007cellular_componentU2-type catalytic step 2 spliceosome
e0071011cellular_componentprecatalytic spliceosome
e0071013cellular_componentcatalytic step 2 spliceosome
e1903241biological_processU2-type prespliceosome assembly
e1990904cellular_componentribonucleoprotein complex
f0000387biological_processspliceosomal snRNP assembly
f0000398biological_processmRNA splicing, via spliceosome
f0003723molecular_functionRNA binding
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005681cellular_componentspliceosomal complex
f0005682cellular_componentU5 snRNP
f0005683cellular_componentU7 snRNP
f0005684cellular_componentU2-type spliceosomal complex
f0005685cellular_componentU1 snRNP
f0005686cellular_componentU2 snRNP
f0005687cellular_componentU4 snRNP
f0005689cellular_componentU12-type spliceosomal complex
f0005737cellular_componentcytoplasm
f0005829cellular_componentcytosol
f0006397biological_processmRNA processing
f0008380biological_processRNA splicing
f0022618biological_processprotein-RNA complex assembly
f0030532cellular_componentsmall nuclear ribonucleoprotein complex
f0034709cellular_componentmethylosome
f0034715cellular_componentpICln-Sm protein complex
f0034719cellular_componentSMN-Sm protein complex
f0036261biological_process7-methylguanosine cap hypermethylation
f0046540cellular_componentU4/U6 x U5 tri-snRNP complex
f0071005cellular_componentU2-type precatalytic spliceosome
f0071007cellular_componentU2-type catalytic step 2 spliceosome
f0071013cellular_componentcatalytic step 2 spliceosome
f1903241biological_processU2-type prespliceosome assembly
f1990904cellular_componentribonucleoprotein complex
g0000245biological_processspliceosomal complex assembly
g0000387biological_processspliceosomal snRNP assembly
g0000398biological_processmRNA splicing, via spliceosome
g0003723molecular_functionRNA binding
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0005654cellular_componentnucleoplasm
g0005681cellular_componentspliceosomal complex
g0005682cellular_componentU5 snRNP
g0005683cellular_componentU7 snRNP
g0005684cellular_componentU2-type spliceosomal complex
g0005685cellular_componentU1 snRNP
g0005686cellular_componentU2 snRNP
g0005687cellular_componentU4 snRNP
g0005689cellular_componentU12-type spliceosomal complex
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0006397biological_processmRNA processing
g0008380biological_processRNA splicing
g0030532cellular_componentsmall nuclear ribonucleoprotein complex
g0034709cellular_componentmethylosome
g0034719cellular_componentSMN-Sm protein complex
g0036261biological_process7-methylguanosine cap hypermethylation
g0043186cellular_componentP granule
g0046540cellular_componentU4/U6 x U5 tri-snRNP complex
g0071004cellular_componentU2-type prespliceosome
g0071005cellular_componentU2-type precatalytic spliceosome
g0071007cellular_componentU2-type catalytic step 2 spliceosome
g0071011cellular_componentprecatalytic spliceosome
g0071013cellular_componentcatalytic step 2 spliceosome
g0097526cellular_componentspliceosomal tri-snRNP complex
g1903241biological_processU2-type prespliceosome assembly
g1990904cellular_componentribonucleoprotein complex
h0000245biological_processspliceosomal complex assembly
h0000387biological_processspliceosomal snRNP assembly
h0000398biological_processmRNA splicing, via spliceosome
h0003723molecular_functionRNA binding
h0005515molecular_functionprotein binding
h0005634cellular_componentnucleus
h0005654cellular_componentnucleoplasm
h0005681cellular_componentspliceosomal complex
h0005682cellular_componentU5 snRNP
h0005684cellular_componentU2-type spliceosomal complex
h0005685cellular_componentU1 snRNP
h0005686cellular_componentU2 snRNP
h0005687cellular_componentU4 snRNP
h0005689cellular_componentU12-type spliceosomal complex
h0005737cellular_componentcytoplasm
h0005829cellular_componentcytosol
h0006397biological_processmRNA processing
h0008380biological_processRNA splicing
h0030532cellular_componentsmall nuclear ribonucleoprotein complex
h0034709cellular_componentmethylosome
h0034715cellular_componentpICln-Sm protein complex
h0034719cellular_componentSMN-Sm protein complex
h0036261biological_process7-methylguanosine cap hypermethylation
h0046540cellular_componentU4/U6 x U5 tri-snRNP complex
h0070062cellular_componentextracellular exosome
h0071005cellular_componentU2-type precatalytic spliceosome
h0071007cellular_componentU2-type catalytic step 2 spliceosome
h0071011cellular_componentprecatalytic spliceosome
h0071013cellular_componentcatalytic step 2 spliceosome
h0097525cellular_componentspliceosomal snRNP complex
h1903241biological_processU2-type prespliceosome assembly
h1990904cellular_componentribonucleoprotein complex
i0000387biological_processspliceosomal snRNP assembly
i0000398biological_processmRNA splicing, via spliceosome
i0003723molecular_functionRNA binding
i0005515molecular_functionprotein binding
i0005634cellular_componentnucleus
i0005654cellular_componentnucleoplasm
i0005681cellular_componentspliceosomal complex
i0005682cellular_componentU5 snRNP
i0005683cellular_componentU7 snRNP
i0005684cellular_componentU2-type spliceosomal complex
i0005685cellular_componentU1 snRNP
i0005686cellular_componentU2 snRNP
i0005687cellular_componentU4 snRNP
i0005689cellular_componentU12-type spliceosomal complex
i0005737cellular_componentcytoplasm
i0005829cellular_componentcytosol
i0006397biological_processmRNA processing
i0008380biological_processRNA splicing
i0022618biological_processprotein-RNA complex assembly
i0030532cellular_componentsmall nuclear ribonucleoprotein complex
i0034709cellular_componentmethylosome
i0034715cellular_componentpICln-Sm protein complex
i0034719cellular_componentSMN-Sm protein complex
i0036261biological_process7-methylguanosine cap hypermethylation
i0046540cellular_componentU4/U6 x U5 tri-snRNP complex
i0071005cellular_componentU2-type precatalytic spliceosome
i0071007cellular_componentU2-type catalytic step 2 spliceosome
i0071013cellular_componentcatalytic step 2 spliceosome
i1903241biological_processU2-type prespliceosome assembly
i1990904cellular_componentribonucleoprotein complex
j0000245biological_processspliceosomal complex assembly
j0000387biological_processspliceosomal snRNP assembly
j0000398biological_processmRNA splicing, via spliceosome
j0003723molecular_functionRNA binding
j0005515molecular_functionprotein binding
j0005634cellular_componentnucleus
j0005654cellular_componentnucleoplasm
j0005681cellular_componentspliceosomal complex
j0005682cellular_componentU5 snRNP
j0005683cellular_componentU7 snRNP
j0005684cellular_componentU2-type spliceosomal complex
j0005685cellular_componentU1 snRNP
j0005686cellular_componentU2 snRNP
j0005687cellular_componentU4 snRNP
j0005689cellular_componentU12-type spliceosomal complex
j0005697cellular_componenttelomerase holoenzyme complex
j0005737cellular_componentcytoplasm
j0005829cellular_componentcytosol
j0006397biological_processmRNA processing
j0008380biological_processRNA splicing
j0030532cellular_componentsmall nuclear ribonucleoprotein complex
j0034709cellular_componentmethylosome
j0034715cellular_componentpICln-Sm protein complex
j0034719cellular_componentSMN-Sm protein complex
j0036261biological_process7-methylguanosine cap hypermethylation
j0046540cellular_componentU4/U6 x U5 tri-snRNP complex
j0071005cellular_componentU2-type precatalytic spliceosome
j0071007cellular_componentU2-type catalytic step 2 spliceosome
j0071011cellular_componentprecatalytic spliceosome
j0071013cellular_componentcatalytic step 2 spliceosome
j1903241biological_processU2-type prespliceosome assembly
j1990904cellular_componentribonucleoprotein complex
k0000245biological_processspliceosomal complex assembly
k0000387biological_processspliceosomal snRNP assembly
k0000398biological_processmRNA splicing, via spliceosome
k0003723molecular_functionRNA binding
k0005515molecular_functionprotein binding
k0005634cellular_componentnucleus
k0005654cellular_componentnucleoplasm
k0005681cellular_componentspliceosomal complex
k0005682cellular_componentU5 snRNP
k0005683cellular_componentU7 snRNP
k0005684cellular_componentU2-type spliceosomal complex
k0005685cellular_componentU1 snRNP
k0005686cellular_componentU2 snRNP
k0005687cellular_componentU4 snRNP
k0005689cellular_componentU12-type spliceosomal complex
k0005737cellular_componentcytoplasm
k0005829cellular_componentcytosol
k0006397biological_processmRNA processing
k0008380biological_processRNA splicing
k0030532cellular_componentsmall nuclear ribonucleoprotein complex
k0034709cellular_componentmethylosome
k0034719cellular_componentSMN-Sm protein complex
k0036261biological_process7-methylguanosine cap hypermethylation
k0043186cellular_componentP granule
k0046540cellular_componentU4/U6 x U5 tri-snRNP complex
k0071004cellular_componentU2-type prespliceosome
k0071005cellular_componentU2-type precatalytic spliceosome
k0071007cellular_componentU2-type catalytic step 2 spliceosome
k0071011cellular_componentprecatalytic spliceosome
k0071013cellular_componentcatalytic step 2 spliceosome
k0097526cellular_componentspliceosomal tri-snRNP complex
k1903241biological_processU2-type prespliceosome assembly
k1990904cellular_componentribonucleoprotein complex
l0000243cellular_componentcommitment complex
l0000387biological_processspliceosomal snRNP assembly
l0000398biological_processmRNA splicing, via spliceosome
l0003723molecular_functionRNA binding
l0005515molecular_functionprotein binding
l0005634cellular_componentnucleus
l0005654cellular_componentnucleoplasm
l0005681cellular_componentspliceosomal complex
l0005682cellular_componentU5 snRNP
l0005683cellular_componentU7 snRNP
l0005684cellular_componentU2-type spliceosomal complex
l0005685cellular_componentU1 snRNP
l0005686cellular_componentU2 snRNP
l0005687cellular_componentU4 snRNP
l0005689cellular_componentU12-type spliceosomal complex
l0005697cellular_componenttelomerase holoenzyme complex
l0005737cellular_componentcytoplasm
l0005829cellular_componentcytosol
l0006396biological_processRNA processing
l0006397biological_processmRNA processing
l0006479biological_processprotein methylation
l0008380biological_processRNA splicing
l0016604cellular_componentnuclear body
l0019899molecular_functionenzyme binding
l0030532cellular_componentsmall nuclear ribonucleoprotein complex
l0034709cellular_componentmethylosome
l0034715cellular_componentpICln-Sm protein complex
l0034719cellular_componentSMN-Sm protein complex
l0036261biological_process7-methylguanosine cap hypermethylation
l0046540cellular_componentU4/U6 x U5 tri-snRNP complex
l0070034molecular_functiontelomerase RNA binding
l0071005cellular_componentU2-type precatalytic spliceosome
l0071007cellular_componentU2-type catalytic step 2 spliceosome
l0071011cellular_componentprecatalytic spliceosome
l0071013cellular_componentcatalytic step 2 spliceosome
l0071208molecular_functionhistone pre-mRNA DCP binding
l0071209molecular_functionU7 snRNA binding
l0097526cellular_componentspliceosomal tri-snRNP complex
l1903241biological_processU2-type prespliceosome assembly
l1990904cellular_componentribonucleoprotein complex
m0000387biological_processspliceosomal snRNP assembly
m0000398biological_processmRNA splicing, via spliceosome
m0003723molecular_functionRNA binding
m0005515molecular_functionprotein binding
m0005634cellular_componentnucleus
m0005654cellular_componentnucleoplasm
m0005681cellular_componentspliceosomal complex
m0005682cellular_componentU5 snRNP
m0005683cellular_componentU7 snRNP
m0005684cellular_componentU2-type spliceosomal complex
m0005685cellular_componentU1 snRNP
m0005686cellular_componentU2 snRNP
m0005687cellular_componentU4 snRNP
m0005689cellular_componentU12-type spliceosomal complex
m0005697cellular_componenttelomerase holoenzyme complex
m0005737cellular_componentcytoplasm
m0005829cellular_componentcytosol
m0006397biological_processmRNA processing
m0006479biological_processprotein methylation
m0008380biological_processRNA splicing
m0030532cellular_componentsmall nuclear ribonucleoprotein complex
m0034709cellular_componentmethylosome
m0034719cellular_componentSMN-Sm protein complex
m0036261biological_process7-methylguanosine cap hypermethylation
m0046540cellular_componentU4/U6 x U5 tri-snRNP complex
m0070034molecular_functiontelomerase RNA binding
m0070990molecular_functionsnRNP binding
m0071004cellular_componentU2-type prespliceosome
m0071005cellular_componentU2-type precatalytic spliceosome
m0071007cellular_componentU2-type catalytic step 2 spliceosome
m0071013cellular_componentcatalytic step 2 spliceosome
m0071204cellular_componenthistone pre-mRNA 3'end processing complex
m0071208molecular_functionhistone pre-mRNA DCP binding
m1903241biological_processU2-type prespliceosome assembly
m1990446molecular_functionU1 snRNP binding
m1990447molecular_functionU2 snRNP binding
m1990904cellular_componentribonucleoprotein complex
n0000243cellular_componentcommitment complex
n0000245biological_processspliceosomal complex assembly
n0000387biological_processspliceosomal snRNP assembly
n0000398biological_processmRNA splicing, via spliceosome
n0003723molecular_functionRNA binding
n0005515molecular_functionprotein binding
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005681cellular_componentspliceosomal complex
n0005682cellular_componentU5 snRNP
n0005684cellular_componentU2-type spliceosomal complex
n0005685cellular_componentU1 snRNP
n0005686cellular_componentU2 snRNP
n0005687cellular_componentU4 snRNP
n0005689cellular_componentU12-type spliceosomal complex
n0005737cellular_componentcytoplasm
n0005829cellular_componentcytosol
n0006396biological_processRNA processing
n0006397biological_processmRNA processing
n0008380biological_processRNA splicing
n0030532cellular_componentsmall nuclear ribonucleoprotein complex
n0034709cellular_componentmethylosome
n0034715cellular_componentpICln-Sm protein complex
n0034719cellular_componentSMN-Sm protein complex
n0036261biological_process7-methylguanosine cap hypermethylation
n0046540cellular_componentU4/U6 x U5 tri-snRNP complex
n0071005cellular_componentU2-type precatalytic spliceosome
n0071007cellular_componentU2-type catalytic step 2 spliceosome
n0071011cellular_componentprecatalytic spliceosome
n0071013cellular_componentcatalytic step 2 spliceosome
n0097526cellular_componentspliceosomal tri-snRNP complex
n1903241biological_processU2-type prespliceosome assembly
n1990446molecular_functionU1 snRNP binding
n1990904cellular_componentribonucleoprotein complex
o0000398biological_processmRNA splicing, via spliceosome
o0000413biological_processprotein peptidyl-prolyl isomerization
o0003676molecular_functionnucleic acid binding
o0003723molecular_functionRNA binding
o0003729molecular_functionmRNA binding
o0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
o0005515molecular_functionprotein binding
o0005576cellular_componentextracellular region
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0005681cellular_componentspliceosomal complex
o0005737cellular_componentcytoplasm
o0005829cellular_componentcytosol
o0006355biological_processregulation of DNA-templated transcription
o0006397biological_processmRNA processing
o0006457biological_processprotein folding
o0008143molecular_functionpoly(A) binding
o0008380biological_processRNA splicing
o0016018molecular_functioncyclosporin A binding
o0016607cellular_componentnuclear speck
o0016853molecular_functionisomerase activity
o0032991cellular_componentprotein-containing complex
o0034774cellular_componentsecretory granule lumen
o0045070biological_processpositive regulation of viral genome replication
o0071007cellular_componentU2-type catalytic step 2 spliceosome
o0071013cellular_componentcatalytic step 2 spliceosome
o1904813cellular_componentficolin-1-rich granule lumen
p0005634cellular_componentnucleus
p0005654cellular_componentnucleoplasm
p0019899molecular_functionenzyme binding
p0035861cellular_componentsite of double-strand break
q0000166molecular_functionnucleotide binding
q0000354biological_processcis assembly of pre-catalytic spliceosome
q0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
q0000398biological_processmRNA splicing, via spliceosome
q0001649biological_processosteoblast differentiation
q0003676molecular_functionnucleic acid binding
q0003723molecular_functionRNA binding
q0003724molecular_functionRNA helicase activity
q0004386molecular_functionhelicase activity
q0005515molecular_functionprotein binding
q0005524molecular_functionATP binding
q0005634cellular_componentnucleus
q0005654cellular_componentnucleoplasm
q0005681cellular_componentspliceosomal complex
q0005682cellular_componentU5 snRNP
q0005886cellular_componentplasma membrane
q0005929cellular_componentcilium
q0006397biological_processmRNA processing
q0008380biological_processRNA splicing
q0016020cellular_componentmembrane
q0016787molecular_functionhydrolase activity
q0016887molecular_functionATP hydrolysis activity
q0030532cellular_componentsmall nuclear ribonucleoprotein complex
q0042802molecular_functionidentical protein binding
q0046540cellular_componentU4/U6 x U5 tri-snRNP complex
q0071005cellular_componentU2-type precatalytic spliceosome
q0071006cellular_componentU2-type catalytic step 1 spliceosome
q0071013cellular_componentcatalytic step 2 spliceosome
r0000166molecular_functionnucleotide binding
r0000398biological_processmRNA splicing, via spliceosome
r0003676molecular_functionnucleic acid binding
r0003723molecular_functionRNA binding
r0003724molecular_functionRNA helicase activity
r0004386molecular_functionhelicase activity
r0005515molecular_functionprotein binding
r0005524molecular_functionATP binding
r0005634cellular_componentnucleus
r0005654cellular_componentnucleoplasm
r0005681cellular_componentspliceosomal complex
r0006397biological_processmRNA processing
r0008186molecular_functionATP-dependent activity, acting on RNA
r0008380biological_processRNA splicing
r0016020cellular_componentmembrane
r0016787molecular_functionhydrolase activity
r0016887molecular_functionATP hydrolysis activity
r0034458molecular_function3'-5' RNA helicase activity
r0071013cellular_componentcatalytic step 2 spliceosome
r1990904cellular_componentribonucleoprotein complex
s0000350biological_processgeneration of catalytic spliceosome for second transesterification step
s0000389biological_processmRNA 3'-splice site recognition
s0000398biological_processmRNA splicing, via spliceosome
s0000974cellular_componentPrp19 complex
s0003723molecular_functionRNA binding
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005654cellular_componentnucleoplasm
s0005681cellular_componentspliceosomal complex
s0006397biological_processmRNA processing
s0008380biological_processRNA splicing
s0071006cellular_componentU2-type catalytic step 1 spliceosome
s0071013cellular_componentcatalytic step 2 spliceosome
s0071014cellular_componentpost-mRNA release spliceosomal complex
s0071020cellular_componentpost-spliceosomal complex
u0000349biological_processgeneration of catalytic spliceosome for first transesterification step
u0000398biological_processmRNA splicing, via spliceosome
u0005515molecular_functionprotein binding
u0005634cellular_componentnucleus
u0005654cellular_componentnucleoplasm
u0005681cellular_componentspliceosomal complex
u0006397biological_processmRNA processing
u0008380biological_processRNA splicing
u0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
u0046872molecular_functionmetal ion binding
u0071006cellular_componentU2-type catalytic step 1 spliceosome
v0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
v0000381biological_processregulation of alternative mRNA splicing, via spliceosome
v0000398biological_processmRNA splicing, via spliceosome
v0003723molecular_functionRNA binding
v0005515molecular_functionprotein binding
v0005634cellular_componentnucleus
v0005654cellular_componentnucleoplasm
v0005681cellular_componentspliceosomal complex
v0005737cellular_componentcytoplasm
v0005829cellular_componentcytosol
v0006397biological_processmRNA processing
v0006406biological_processmRNA export from nucleus
v0006417biological_processregulation of translation
v0008380biological_processRNA splicing
v0016607cellular_componentnuclear speck
v0035145cellular_componentexon-exon junction complex
v0050684biological_processregulation of mRNA processing
v0051028biological_processmRNA transport
v0071013cellular_componentcatalytic step 2 spliceosome
v1990501cellular_componentexon-exon junction subcomplex mago-y14
v2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
w0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
w0000381biological_processregulation of alternative mRNA splicing, via spliceosome
w0000398biological_processmRNA splicing, via spliceosome
w0003676molecular_functionnucleic acid binding
w0003723molecular_functionRNA binding
w0003729molecular_functionmRNA binding
w0005515molecular_functionprotein binding
w0005634cellular_componentnucleus
w0005654cellular_componentnucleoplasm
w0005681cellular_componentspliceosomal complex
w0005737cellular_componentcytoplasm
w0005829cellular_componentcytosol
w0006396biological_processRNA processing
w0006397biological_processmRNA processing
w0006406biological_processmRNA export from nucleus
w0006417biological_processregulation of translation
w0008380biological_processRNA splicing
w0016607cellular_componentnuclear speck
w0030425cellular_componentdendrite
w0035145cellular_componentexon-exon junction complex
w0043025cellular_componentneuronal cell body
w0050684biological_processregulation of mRNA processing
w0051028biological_processmRNA transport
w0071006cellular_componentU2-type catalytic step 1 spliceosome
w0071013cellular_componentcatalytic step 2 spliceosome
w1990501cellular_componentexon-exon junction subcomplex mago-y14
w2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
x0000398biological_processmRNA splicing, via spliceosome
x0003723molecular_functionRNA binding
x0003779molecular_functionactin binding
x0005515molecular_functionprotein binding
x0005634cellular_componentnucleus
x0005681cellular_componentspliceosomal complex
x0005730cellular_componentnucleolus
x0005737cellular_componentcytoplasm
x0006364biological_processrRNA processing
x0006397biological_processmRNA processing
x0007517biological_processmuscle organ development
x0008380biological_processRNA splicing
x0015030cellular_componentCajal body
x0030018cellular_componentZ disc
x0042254biological_processribosome biogenesis
x0051015molecular_functionactin filament binding
x0055120cellular_componentstriated muscle dense body
x0071013cellular_componentcatalytic step 2 spliceosome
y0000166molecular_functionnucleotide binding
y0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
y0000398biological_processmRNA splicing, via spliceosome
y0003676molecular_functionnucleic acid binding
y0003723molecular_functionRNA binding
y0003724molecular_functionRNA helicase activity
y0003729molecular_functionmRNA binding
y0004386molecular_functionhelicase activity
y0005515molecular_functionprotein binding
y0005524molecular_functionATP binding
y0005634cellular_componentnucleus
y0005654cellular_componentnucleoplasm
y0005681cellular_componentspliceosomal complex
y0005730cellular_componentnucleolus
y0005737cellular_componentcytoplasm
y0005829cellular_componentcytosol
y0006364biological_processrRNA processing
y0006397biological_processmRNA processing
y0006406biological_processmRNA export from nucleus
y0006417biological_processregulation of translation
y0008143molecular_functionpoly(A) binding
y0008306biological_processassociative learning
y0008380biological_processRNA splicing
y0010629biological_processnegative regulation of gene expression
y0016020cellular_componentmembrane
y0016607cellular_componentnuclear speck
y0016787molecular_functionhydrolase activity
y0016887molecular_functionATP hydrolysis activity
y0017148biological_processnegative regulation of translation
y0030425cellular_componentdendrite
y0035145cellular_componentexon-exon junction complex
y0035368molecular_functionselenocysteine insertion sequence binding
y0035613molecular_functionRNA stem-loop binding
y0035640biological_processexploration behavior
y0043021molecular_functionribonucleoprotein complex binding
y0043025cellular_componentneuronal cell body
y0045727biological_processpositive regulation of translation
y0048701biological_processembryonic cranial skeleton morphogenesis
y0051028biological_processmRNA transport
y0071006cellular_componentU2-type catalytic step 1 spliceosome
y0071013cellular_componentcatalytic step 2 spliceosome
y0072715biological_processcellular response to selenite ion
y0090394biological_processnegative regulation of excitatory postsynaptic potential
y0098794cellular_componentpostsynapse
y0098978cellular_componentglutamatergic synapse
y0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
y1904570biological_processnegative regulation of selenocysteine incorporation
y1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
y1990904cellular_componentribonucleoprotein complex
y2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
z0000398biological_processmRNA splicing, via spliceosome
z0000413biological_processprotein peptidyl-prolyl isomerization
z0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
z0005634cellular_componentnucleus
z0005654cellular_componentnucleoplasm
z0005681cellular_componentspliceosomal complex
z0006397biological_processmRNA processing
z0006457biological_processprotein folding
z0008380biological_processRNA splicing
z0016604cellular_componentnuclear body
z0016853molecular_functionisomerase activity
z0071013cellular_componentcatalytic step 2 spliceosome
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
yVAL185-LEU193

site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. FkgSsFHRIIpqFMcQGG
ChainResidueDetails
oPHE184-GLY201

site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. EETqlDIVGIWWTV
ChainResidueDetails
xGLU37-VAL50

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAadDsSVKLWDL
ChainResidueDetails
GLEU407-LEU421
ELEU304-VAL318
pLEU197-PHE211

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SaIIMDEAHE
ChainResidueDetails
rSER647-GLU656

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues78
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues77
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues82
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues78
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues41
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues30
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues9
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues32
DetailsRepeat: {"description":"HAT 2","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues32
DetailsRepeat: {"description":"HAT 3","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues34
DetailsRepeat: {"description":"HAT 4","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues32
DetailsRepeat: {"description":"HAT 5","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues32
DetailsRepeat: {"description":"HAT 6"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues33
DetailsRepeat: {"description":"HAT 7"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues35
DetailsRepeat: {"description":"HAT 8"}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues38
DetailsRepeat: {"description":"HAT 9"}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues65
DetailsRepeat: {"description":"HAT 11"}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues66
DetailsRepeat: {"description":"HAT 12"}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues68
DetailsRepeat: {"description":"HAT 13"}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues34
DetailsRepeat: {"description":"HAT 14"}
ChainResidueDetails

site_idSWS_FT_FI21
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI23
Number of Residues151
DetailsDomain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI24
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI25
Number of Residues32
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI26
Number of Residues183
DetailsDomain: {"description":"MIF4G","evidences":[{"source":"PROSITE-ProRule","id":"PRU00698","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI27
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25599396","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI28
Number of Residues21
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails

site_idSWS_FT_FI29
Number of Residues21
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails

site_idSWS_FT_FI30
Number of Residues21
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails

site_idSWS_FT_FI31
Number of Residues21
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails

site_idSWS_FT_FI32
Number of Residues38
DetailsDomain: {"description":"LRRCT"}
ChainResidueDetails

site_idSWS_FT_FI33
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI34
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI35
Number of Residues79
DetailsDomain: {"description":"RRM 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI36
Number of Residues362
DetailsDomain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI37
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI38
Number of Residues158
DetailsRegion: {"description":"Sufficient for interaction with CLNS1A","evidences":[{"source":"PubMed","id":"11747828","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI39
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}}]}
ChainResidueDetails

site_idSWS_FT_FI40
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI41
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI42
Number of Residues183
DetailsDomain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI43
Number of Residues237
DetailsDomain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI44
Number of Residues305
DetailsDomain: {"description":"SEC63 1"}
ChainResidueDetails

site_idSWS_FT_FI45
Number of Residues175
DetailsDomain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI46
Number of Residues208
DetailsDomain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI47
Number of Residues312
DetailsDomain: {"description":"SEC63 2"}
ChainResidueDetails

site_idSWS_FT_FI48
Number of Residues3
DetailsMotif: {"description":"DEIH box"}
ChainResidueDetails

site_idSWS_FT_FI49
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails

site_idSWS_FT_FI50
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI51
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI52
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI53
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails

site_idSWS_FT_FI54
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI55
Number of Residues170
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI56
Number of Residues161
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI57
Number of Residues28
DetailsMotif: {"description":"Q motif"}
ChainResidueDetails

site_idSWS_FT_FI58
Number of Residues3
DetailsMotif: {"description":"DEAD box","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI59
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16923391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16931718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19033377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20479275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HYI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EX7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI60
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60842","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI61
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI62
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60843","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI63
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P60842","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI64
Number of Residues155
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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