7A3P

Crystal structure of dengue 3 virus envelope glycoprotein in complex with the scFv fragment of the broadly neutralizing human antibody EDE1 C10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Envelope protein E	polymer	428	46820.2	2	UniProt (Q07019) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (O39791)	Dengue virus 3	Matrix protein,Peptide pr,Protein prM,Small envelope protein M
2	C, E (H, I)	Single Chain Variable Fragment	polymer	144	15679.2	2		Homo sapiens (Human)
3	D, F (L, M)	Single Chain Variable Fragment	polymer	154	15632.8	2		Homo sapiens (Human)
4	G (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	H, I, J, K, L... (A, B, H, L, I...)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 1 - 393 (UniProt: Q07019)

PDB	External Database	Details
Leu 394	-	expression tag
Val 395	-	expression tag
Pro 396	-	expression tag
Arg 397	-	expression tag
Gly 398	-	expression tag
Ser 399	-	expression tag
Ser 400	-	expression tag
Ala 401	-	expression tag
Trp 402	-	expression tag
Ser 403	-	expression tag
His 404	-	expression tag
Pro 405	-	expression tag
Gln 406	-	expression tag
Phe 407	-	expression tag
Glu 408	-	expression tag
Lys 409	-	expression tag
Gly 410	-	expression tag
Gly 411	-	expression tag
Ser 412	-	expression tag
Gly 413	-	expression tag
Gly 414	-	expression tag
Gly 415	-	expression tag
Ser 416	-	expression tag
Gly 417	-	expression tag
Gly 418	-	expression tag
Ser 419	-	expression tag
Ala 420	-	expression tag
Trp 421	-	expression tag
Ser 422	-	expression tag
His 423	-	expression tag
Pro 424	-	expression tag
Gln 425	-	expression tag
Phe 426	-	expression tag
Glu 427	-	expression tag
Lys 428	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	156264.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	156485.6

*Water molecules are not included.