7A38
Crystal structure of the c-Src SH3 domain mutant V111L-N113S-T114S-Q128E at pH 6.0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 60 | 6723.3 | 2 | UniProt (P00523) Pfam (PF00018) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | C (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A, B: 82 - 141 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Leu 111 | Val 111 | engineered mutation |
| Ser 113 | Asn 113 | engineered mutation |
| Ser 114 | Thr 114 | engineered mutation |
| Glu 128 | Gln 128 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 13446.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 291.3 | |
| All* | Total formula weight | 13737.8 |
