6ZWO
cryo-EM structure of human mTOR complex 2, focused on one half
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Serine/threonine-protein kinase mTOR | polymer | 2549 | 289258.0 | 1 | UniProt (P42345) Pfam (PF11865) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (Human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
| 2 | B (D) | Target of rapamycin complex subunit LST8 | polymer | 326 | 35910.1 | 1 | UniProt (Q9BVC4) Pfam (PF00400) | Homo sapiens (Human) | TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8 |
| 3 | C (F) | Rapamycin-insensitive companion of mTOR | polymer | 1708 | 192472.9 | 1 | UniProt (Q6R327) Pfam (PF14664) Pfam (PF14666) Pfam (PF14663) Pfam (PF14668) Pfam (PF14665) | Homo sapiens (Human) | AVO3 homolog,hAVO3 |
| 4 | D (H) | Target of rapamycin complex 2 subunit MAPKAP1 | polymer | 521 | 59075.6 | 1 | UniProt (Q9BPZ7) Pfam (PF05422) Pfam (PF16978) Pfam (PF16979) | Homo sapiens (Human) | TORC2 subunit MAPKAP1,Mitogen-activated protein kinase 2-associated protein 1,Stress-activated map kinase-interacting protein 1,mSIN1 |
| 5 | E, H (B, F) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 2 | Chemie (AGS) | |||
| 6 | F (B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 7 | G (F) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | I (H) | ACETYL GROUP | non-polymer | 44.1 | 1 | Chemie (ACE) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 576716.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1816.0 | |
| All* | Total formula weight | 578532.5 |
