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6ZWO

cryo-EM structure of human mTOR complex 2, focused on one half

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0001932biological_processregulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006468biological_processprotein phosphorylation
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007040biological_processlysosome organization
B0007281biological_processgerm cell development
B0007584biological_processresponse to nutrient
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009791biological_processpost-embryonic development
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010628biological_processpositive regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016605cellular_componentPML body
B0018105biological_processpeptidyl-serine phosphorylation
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030163biological_processprotein catabolic process
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035264biological_processmulticellular organism growth
B0038202biological_processTORC1 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0044877molecular_functionprotein-containing complex binding
B0045335cellular_componentphagocytic vesicle
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045948biological_processpositive regulation of translational initiation
B0046777biological_processprotein autophosphorylation
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048511biological_processrhythmic process
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050882biological_processvoluntary musculoskeletal movement
B0051128biological_processregulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051247biological_processpositive regulation of protein metabolic process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051647biological_processnucleus localization
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0106310molecular_functionprotein serine kinase activity
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1904059biological_processregulation of locomotor rhythm
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990253biological_processcellular response to leucine starvation
B2000785biological_processregulation of autophagosome assembly
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006974biological_processDNA damage response
D0007010biological_processcytoskeleton organization
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0030307biological_processpositive regulation of cell growth
D0030838biological_processpositive regulation of actin filament polymerization
D0031669biological_processcellular response to nutrient levels
D0031929biological_processTOR signaling
D0031931cellular_componentTORC1 complex
D0031932cellular_componentTORC2 complex
D0032008biological_processpositive regulation of TOR signaling
D0032956biological_processregulation of actin cytoskeleton organization
D0038202biological_processTORC1 signaling
D0043066biological_processnegative regulation of apoptotic process
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0045821biological_processpositive regulation of glycolytic process
D0046889biological_processpositive regulation of lipid biosynthetic process
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0071456biological_processcellular response to hypoxia
D0071470biological_processcellular response to osmotic stress
D1905857biological_processpositive regulation of pentose-phosphate shunt
F0001932biological_processregulation of protein phosphorylation
F0001938biological_processpositive regulation of endothelial cell proliferation
F0005515molecular_functionprotein binding
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0007010biological_processcytoskeleton organization
F0009792biological_processembryo development ending in birth or egg hatching
F0010468biological_processregulation of gene expression
F0018105biological_processpeptidyl-serine phosphorylation
F0019901molecular_functionprotein kinase binding
F0030036biological_processactin cytoskeleton organization
F0030307biological_processpositive regulation of cell growth
F0030838biological_processpositive regulation of actin filament polymerization
F0031669biological_processcellular response to nutrient levels
F0031929biological_processTOR signaling
F0031932cellular_componentTORC2 complex
F0032008biological_processpositive regulation of TOR signaling
F0032956biological_processregulation of actin cytoskeleton organization
F0033135biological_processregulation of peptidyl-serine phosphorylation
F0038203biological_processTORC2 signaling
F0042325biological_processregulation of phosphorylation
F0043022molecular_functionribosome binding
F0043066biological_processnegative regulation of apoptotic process
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0050727biological_processregulation of inflammatory response
F0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
F0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0060090molecular_functionmolecular adaptor activity
F2000114biological_processregulation of establishment of cell polarity
H0005515molecular_functionprotein binding
H0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
H0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0007010biological_processcytoskeleton organization
H0019901molecular_functionprotein kinase binding
H0021762biological_processsubstantia nigra development
H0030307biological_processpositive regulation of cell growth
H0031267molecular_functionsmall GTPase binding
H0031410cellular_componentcytoplasmic vesicle
H0031669biological_processcellular response to nutrient levels
H0031932cellular_componentTORC2 complex
H0033138biological_processpositive regulation of peptidyl-serine phosphorylation
H0038203biological_processTORC2 signaling
H0043066biological_processnegative regulation of apoptotic process
H0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
H0046580biological_processnegative regulation of Ras protein signal transduction
H0060090molecular_functionmolecular adaptor activity
H0070300molecular_functionphosphatidic acid binding
H0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
H1900407biological_processregulation of cellular response to oxidative stress
Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVDLDS
ChainResidueDetails
HVAL333-SER339

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
DMET100-LEU114

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
BLEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
BSER2323-ASN2343

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.8
ChainResidueDetails
HALA2
BMET2345
BILE2356
BGLN2167
BLEU2185
BGLU2190
BTYR2225
BGLY2238
BTRP2239
BVAL2240
BTHR2245

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
HSER186
FTHR1295
FTHR1332

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
HSER510

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER1162
FSER1278
FSER1302
FSER1313
FSER1346
FSER1353

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6QI06
ChainResidueDetails
FSER1235

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
FSER1282

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
FSER1284
FSER1411

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
FSER1385

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
FSER1388

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976
ChainResidueDetails
FSER1396

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
FSER1591

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by GSK3-alpha and GSK3-beta => ECO:0000269|PubMed:25897075
ChainResidueDetails
FTHR1695

site_idSWS_FT_FI13
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:33378666
ChainResidueDetails
FLYS274

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:21576368, ECO:0007744|PubMed:18669648
ChainResidueDetails
BSER2481

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PDB entries from 2024-07-24

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