6ZU8
Crystal structure of human Brachyury G177D variant in complex with Afatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Brachyury protein | polymer | 192 | 22080.4 | 1 | UniProt (O15178) Pfam (PF00907) | Homo sapiens (Human) | Protein T |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | non-polymer | 488.0 | 1 | Chemie (0WN) | |||
| 4 | D (A) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A: 41 - 225 (UniProt: O15178)
| PDB | External Database | Details |
|---|---|---|
| Met 39 | - | initiating methionine |
| Gly 40 | - | expression tag |
| Asp 177 | Gly 177 | conflict |
| His 226 | - | expression tag |
| His 227 | - | expression tag |
| His 228 | - | expression tag |
| His 229 | - | expression tag |
| His 230 | - | expression tag |
| His 231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22080.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 553.4 | |
| All* | Total formula weight | 22633.8 |
