6ZU8

Crystal structure of human Brachyury G177D variant in complex with Afatinib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS01264
Number of Residues	19
Details	TBOX_2 T-box domain signature 2. IHPDSpnfGahWMkapVsF

Chain	Residue	Details
A	ILE125-PHE143

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site_id	PS01283
Number of Residues	20
Details	TBOX_1 T-box domain signature 1. LWlrFkeltNEMIVTknGRR

Chain	Residue	Details
A	LEU51-ARG70

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