6ZSI

The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Ras-related protein Rab-8A	polymer	178	20476.6	2	UniProt (P61006) Pfam (PF00071)	Homo sapiens (Human)	Oncogene c-mel
2	C, D (C, D)	EH domain-binding protein 1	polymer	156	18594.0	2	UniProt (Q8NDI1) Pfam (PF12130)	Homo sapiens (Human)
3	E, H (A, B)	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	2	Chemie (GNP)
4	F, I (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	G, J (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	K, L, M (A, B, D)	water	water		18.0	42	Chemie (HOH)

Sequence modifications

A, B: 1 - 176 (UniProt: P61006)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

C, D: 1060 - 1212 (UniProt: Q8NDI1)

PDB	External Database	Details
Gly 1057	-	expression tag
His 1058	-	expression tag
Met 1059	-	expression tag
Ala 1116	Met 1116	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	78141.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1305.2
All*	Total formula weight	79446.4

*Water molecules are not included.