6ZS4
Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein polybromo-1 | polymer | 124 | 14648.0 | 1 | UniProt (Q86U86) Pfam (PF00439) | Homo sapiens (Human) | hPB1,BRG1-associated factor 180,BAF180,Polybromo-1D |
| 2 | B (A) | tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate | non-polymer | 371.4 | 1 | Chemie (QP8) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 645 - 766 (UniProt: Q86U86)
| PDB | External Database | Details |
|---|---|---|
| Ser 643 | - | expression tag |
| Met 644 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14648.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 433.5 | |
| All* | Total formula weight | 15081.5 |
