6ZS4

Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue QP8 A 801

Chain	Residue
A	ILE683
A	LYS747
A	PHE684
A	LEU693
A	TYR696
A	MET704
A	ALA735
A	TYR738
A	ASN739
A	ILE745

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 802

Chain	Residue
A	LYS675
A	ARG676
A	LYS701

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY

Chain	Residue	Details
A	SER681-TYR738

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER648

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER689

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS653

---