6ZS2
Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcription activator BRG1 | polymer | 121 | 14230.4 | 2 | UniProt (P51532) Pfam (PF00439) | Homo sapiens (Human) | ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
| 2 | C, E (A, B) | 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol | non-polymer | 272.3 | 2 | Chemie (FX5) | |||
| 3 | D, F (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A, B: 1451 - 1569 (UniProt: P51532)
| PDB | External Database | Details |
|---|---|---|
| Ser 1449 | - | expression tag |
| Met 1450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28460.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 668.8 | |
| All* | Total formula weight | 29129.7 |
