6ZS2
Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue FX5 A 1601 |
| Chain | Residue |
| A | LEU1451 |
| A | ILE1546 |
| A | VAL1484 |
| A | PHE1485 |
| A | LEU1488 |
| A | TYR1497 |
| A | VAL1505 |
| A | ALA1536 |
| A | PHE1539 |
| A | ASN1540 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1602 |
| Chain | Residue |
| A | LYS1511 |
| A | ARG1515 |
| A | HOH1742 |
| A | HOH1775 |
| B | GLU1542 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue FX5 B 1601 |
| Chain | Residue |
| B | LEU1451 |
| B | VAL1484 |
| B | PHE1485 |
| B | LEU1488 |
| B | TYR1497 |
| B | VAL1505 |
| B | ALA1536 |
| B | PHE1539 |
| B | ASN1540 |
| B | ILE1546 |
| B | HOH1760 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1602 |
| Chain | Residue |
| A | ARG1515 |
| B | GLN1537 |
| B | THR1538 |
| B | ASN1540 |
| B | LEU1541 |
| B | GLU1542 |
| B | HOH1772 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslndlekdvml.LcqNAqtF |
| Chain | Residue | Details |
| A | SER1482-PHE1539 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 222 |
| Details | Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for binding to 'Lys-15'-acetylated histone 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
